Miethke T
Technische Universität München, Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, München, Deutschland.
Zentralbl Chir. 2012 Jun;137(3):279-83. doi: 10.1055/s-0031-1271348. Epub 2011 Feb 28.
Multi-resistant bacteria endanger with increasing frequency the successful outcome of antibiotic therapy, which represents the presumably most successful discovery of medicine. Due to a worldwide misuse of antibiotics and combined with a lacking awareness of hospital hygiene, multi-resistant bacteria spread with a worrisome pace within the clinic. These bacteria also spread globally via modern transportation systems. Today bacteria are present in hospitals, which are sensitive to a rather limited number of antibiotics or even -worse are pan-resistant. The growing threat of multi-resistant bacteria is further increased by the fact that the pipeline of the pharmaceutical industry for new antibiotics is more or less empty. Furthermore, economical pressure will increase the workload for hospital employees and by that support the spread of -multi-resistant bacteria. In addition, patients will be more susceptible to infections since on the one hand they are on average of older age and on the other hand treated with more aggressive surgical or immuno-suppressive regimens.
This threatening but realistic future scenario can only be avoided by a combination of measures: absolute justified application of antibiotics, a consequent use of standard hygiene, -isolation of contaminated or infected patients and sufficient employees and their education in the prevention of infections.
多重耐药菌日益频繁地危及抗生素治疗的成功结果，而抗生素治疗大概是医学上最成功的发现。由于全球对抗生素的滥用，再加上医院卫生意识的缺乏，多重耐药菌在诊所内以令人担忧的速度传播。这些细菌还通过现代交通系统在全球范围内传播。如今，医院里存在着对相当有限数量的抗生素敏感甚至更糟的全耐药菌。制药行业新抗生素研发渠道几乎空白这一事实，进一步加剧了多重耐药菌日益增长的威胁。此外，经济压力将增加医院员工的工作量，从而助长多重耐药菌的传播。此外，患者将更容易受到感染，一方面是因为他们平均年龄较大，另一方面是因为他们接受了更激进的手术或免疫抑制治疗方案。
只有通过一系列措施才能避免这种具有威胁性但又现实的未来情况：合理使用抗生素、切实执行标准卫生措施、隔离受污染或感染的患者以及配备足够的员工并对他们进行感染预防教育。
