J Biomed Opt. 2011 Feb;16(2):020504. doi: 10.1117/1.3544504.
We propose a rate process model for describing photochemical damage to retinal cells by short wavelength laser exposures. The rate equation for photochemical damage contains a positive rate that is temperature independent, and a negative (quenching) rate that is temperature dependent. Using the traditional Arrhenius integral to describe thermal damage, we derive damage threshold doses for both thermal and photochemical mechanisms, and show that the model accounts for the sharp transition from thermal to photochemical damage thresholds that have recently been observed in an in-vitro retinal model.
我们提出了一个描述短波长激光辐照对视网膜细胞光化学损伤的速率过程模型。光化学损伤的速率方程包含一个与温度无关的正速率项和一个与温度有关的负（猝灭）速率项。利用传统的 Arrhenius 积分来描述热损伤，我们推导出了热和光化学机制的损伤阈值剂量，并表明该模型解释了最近在体外视网膜模型中观察到的从热损伤到光化学损伤阈值的急剧转变。
