Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Chin Med J (Engl). 2011 Feb;124(4):541-5.
Large drusen is a known risk factor for the development of late complications of age-related macular degeneration (AMD) and drusen reduction has been found by our previous study. To prospectively evaluate the efficacy and safety of prophylactic laser treatment in Chinese patients with bilateral soft drusen, we examined the structure and function of the macula 8 years after treatment.
Ten patients with more than 10 soft drusen (> 125 mm) and best corrected visual acuity ≥ 20/25 in each eye participated in the study. One eye, with relatively more drusen, was exposed to an argon laser (514 nm) to achieve a barely visible retinal lesion. The contralateral eye was used as a control. Fluorescein angiography, Amsler tests, Fourier-domain optical coherence tomography and visual evoked potential tests were carried out 8 years later.
No choroidal neovascularization was seen in the laser-treated eyes or control eyes. There were no significant differences in visual acuity or P100 latency and amplitude between the laser treated eyes and contralateral eyes (t = 1.685, 1.184; P > 0.05). The thickness of the retinal pigment epithelium of the treated eyes was less than that of the contralateral eyes (t = -4.540; P < 0.05). The full retinal thickness in treated eyes was slightly, but insignificantly, reduced relative to contralateral eyes (t = -1.746; P > 0.05).
The treatment was associated with a reduction in retinal pigment epithelium thickness elevation compared with the contralateral eyes. Macular function was not impaired.
大玻璃膜疣是年龄相关性黄斑变性（AMD）晚期并发症发展的已知危险因素，我们之前的研究发现玻璃膜疣减少。为了前瞻性评估预防性激光治疗对双侧软性玻璃膜疣中国患者的疗效和安全性，我们在治疗 8 年后检查了黄斑的结构和功能。
10 例患者每只眼有超过 10 个软性玻璃膜疣（> 125 µm）和最佳矫正视力≥ 20/25 参与了研究。一只眼有较多的玻璃膜疣，暴露于氩激光（514nm）以获得几乎看不见的视网膜病变。对侧眼作为对照。8 年后进行荧光素血管造影、Amsler 测试、傅里叶域光学相干断层扫描和视觉诱发电位测试。
激光治疗眼或对照眼均未见脉络膜新生血管。激光治疗眼和对侧眼之间的视力或 P100 潜伏期和振幅无显著差异（t = 1.685, 1.184; P > 0.05）。治疗眼的视网膜色素上皮厚度小于对侧眼（t = -4.540; P < 0.05）。与对侧眼相比，治疗眼的全视网膜厚度略有但无统计学意义的减少（t = -1.746; P > 0.05）。
与对侧眼相比，治疗后视网膜色素上皮厚度升高减少。黄斑功能未受损。
