Mapping and localization of susceptible genes in asthma.

OBJECTIVE

To elucidate the development of mapping and localization of susceptible genes on chromosomes to asthma related phenotypes.

DATA SOURCES

Published articles about susceptibility genes for asthma related phenotypes were selected using PubMed.

STUDY SELECTION

Using methods of candidate gene positional clone and genome-wide scan with linkage and association analysis to determine the location in the genome of susceptibility genes to asthma and asthma related phenotypes.

RESULTS

There are multiple regions in the genome harboring susceptibility genes to asthma and asthma related phenotypes, including chromosomes 5, 11, 12, 6, 2, 3, 13, 7, 14, 9, 19 and 17. Many of these regions contain candidate genes involved in asthma development and progression. Some susceptible genes may affect the phenotype expression or response to therapy. In addition, the interaction of multiple genes with the environment may contribute to the susceptibility to asthma.

CONCLUSIONS

As an essential step toward cloning the susceptible genes to asthma, fine mapping and localization on chromosomes are definitely needed. Novel powerful tools for gene discovery and the integration of genetics, biology and bioinformatics should be pursued.