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[激素敏感性乳腺癌女性的阴道雌激素治疗]

[Vaginal oestrogen therapy in women with hormone-sensitive breast cancer].

作者信息

Bak Ann Mosegaard, Laursen Britt Elmedal, Rungby Jørgen, Brock Birgitte

机构信息

Klinisk Farmakologisk Afdeling, Århus Universitetshospital, 8000 Aarhus C, Denmark.

出版信息

Ugeskr Laeger. 2011 Feb 28;173(9):648-51.

Abstract

Vaginal atrophy is a common problem in women who have previously been treated for breast cancer. Endocrine therapy plays an essential role in the treatment of breast cancer. Systemic hormonal treatment is contraindicated. Topical oestrogens are an effective treatment for vaginal atrophy, but are poorly studied in this group of patients. Physicians are reluctant to recommend it because of the potential increase in the risk of recurrence. The sparse data available suggest that vaginal oestrogen may be used relatively safely by women who are in tamoxifen treatment, but should not be used by women who receive aromatase inhibitor treatment.

摘要

阴道萎缩是既往接受过乳腺癌治疗的女性中的常见问题。内分泌治疗在乳腺癌治疗中起着至关重要的作用。全身激素治疗是禁忌的。局部使用雌激素是治疗阴道萎缩的有效方法,但在这类患者中对此研究较少。由于复发风险可能增加,医生不愿推荐使用。现有少量数据表明,正在接受他莫昔芬治疗的女性使用阴道雌激素可能相对安全,但接受芳香化酶抑制剂治疗的女性不应使用。

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