Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, PR China.
Lupus. 2011 Mar;20(3):227-30. doi: 10.1177/0961203310389842.
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) (Ets-1) is a member of the Ets family of transcription factors that share a unique Ets DNA binding domain. They control a wide variety of cellular processes including cell proliferation and differentiation. Recently, two genome-wide association studies in systemic lupus erythematosus (SLE) independently identified genetic variants in Ets-1 associated with SLE. Interestingly, previous studies have found that Ets-1-deficient mice develop lupus-like disease characterized by high titers of IgM and IgG autoantibodies, immune complex-mediated glomerulonephritis, and local activation of complement. In addition, Ets-1 is also involved in many cellular abnormalities that are known to participate in SLE pathogenesis, such as its role in negative regulation of Th17 cell and B cell differentiation. All these findings suggest that Ets-1 may play an important role in the pathogenesis of SLE. This article will focus on current understanding of the role of Ets-1 in the physiological and pathological functions associated with SLE. It is the intention of the article to provide insights which may assist in the development of Ets-1 based approaches for the treatment of SLE.
v-ets 红细胞生成素病毒 E26 癌基因同源物 1（禽）（Ets-1）是转录因子 Ets 家族的成员，它们共享独特的 Ets DNA 结合域。它们控制着包括细胞增殖和分化在内的各种细胞过程。最近，两项系统性红斑狼疮（SLE）的全基因组关联研究独立鉴定出 Ets-1 中的遗传变异与 SLE 相关。有趣的是，先前的研究发现，Ets-1 缺陷型小鼠会发展出狼疮样疾病，其特征是 IgM 和 IgG 自身抗体的高滴度、免疫复合物介导的肾小球肾炎和补体的局部激活。此外，Ets-1 还参与了许多已知参与 SLE 发病机制的细胞异常，如其在 Th17 细胞和 B 细胞分化中的负调控作用。所有这些发现表明 Ets-1 可能在 SLE 的发病机制中发挥重要作用。本文将重点介绍目前对 Ets-1 在与 SLE 相关的生理和病理功能中的作用的理解。本文旨在提供见解，可能有助于开发基于 Ets-1 的 SLE 治疗方法。
