Calza L, Masetti G, Piergentili B, Trapani F, Cascavilla A, Manfredi R, Colangeli V, Viale P
Department of Internal Medicine, Geriatrics and Nephrologic Diseases, Section of Infectious Diseases, S. Orsola-Malpighi Hospital, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Int J STD AIDS. 2011 Jan;22(1):43-5. doi: 10.1258/ijsa.2010.010256.
Metabolic complications of antiretroviral therapy in HIV-infected patients include insulin resistance, diabetes mellitus, dyslipidaemia and lipodystrophy syndrome. Metabolic syndrome is an aggregation of central obesity with glucose and lipid metabolism alterations that confers an increased risk of cardiovascular disease, which reproduces the antiretroviral-associated metabolic and morphological abnormalities. In this study, we report the prevalence of diabetes mellitus, hyperinsulinaemia and metabolic syndrome among 755 adult patients with HIV-1 infection referred to our outpatients unit. The prevalence of diabetes mellitus and metabolic syndrome was 4.5% and 9.1%, respectively. A longer exposure to antiretroviral therapy and a diagnosis of lipodystrophy syndrome were significantly associated with both metabolic disturbances.
HIV感染患者抗逆转录病毒治疗的代谢并发症包括胰岛素抵抗、糖尿病、血脂异常和脂肪代谢障碍综合征。代谢综合征是中心性肥胖与糖脂代谢改变的集合，会增加心血管疾病风险，这再现了抗逆转录病毒治疗相关的代谢和形态学异常。在本研究中，我们报告了755例转诊至我院门诊的成年HIV-1感染患者中糖尿病、高胰岛素血症和代谢综合征的患病率。糖尿病和代谢综合征的患病率分别为4.5%和9.1%。抗逆转录病毒治疗暴露时间延长和脂肪代谢障碍综合征诊断与这两种代谢紊乱均显著相关。
