结直肠癌中 microRNA 的失调：临床视角。
MicroRNA dysregulation in colorectal cancer: a clinical perspective.
机构信息
Institute of Digestive Disease and Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.
出版信息
Br J Cancer. 2011 Mar 15;104(6):893-8. doi: 10.1038/bjc.2011.57. Epub 2011 Mar 1.
Abstract
Recent researches have shed light on the biological importance of microRNAs (miRNAs) in colorectal cancer (CRC) genesis, progression and response to treatments. The potential utility of miRNAs in the preclinical stage have been explored and investigated. In this review, we explored the literature and reviewed the cutting edge progress in the discovery of noninvasive plasma and faecal miRNAs for CRC early diagnosis, as well as their measurability and predictability. We also discussed the utility of miRNAs as novel prognostic and predictive markers, and their association with CRC clinical phenotypes including recurrence, metastasis and therapeutic outcomes. Finally, we summarised miRNA-related single-nucleotide polymorphisms and their potential influence on sporadic CRC susceptibility and therapeutic response. In conclusion, the use of miRNAs as biomarker for CRC is still in its infancy and need further characterisation and evaluation.
摘要
最近的研究揭示了 microRNAs（miRNAs）在结直肠癌（CRC）发生、发展和对治疗反应中的生物学重要性。miRNAs 在临床前阶段的潜在应用已经得到了探索和研究。在这篇综述中，我们查阅了文献，综述了非侵入性血浆和粪便 miRNAs 用于 CRC 早期诊断的最新进展，以及它们的可测量性和可预测性。我们还讨论了 miRNAs 作为新型预后和预测标志物的效用，以及它们与 CRC 临床表型（包括复发、转移和治疗结果）的关联。最后，我们总结了 miRNA 相关的单核苷酸多态性及其对散发性 CRC 易感性和治疗反应的潜在影响。总之，miRNAs 作为 CRC 生物标志物的应用仍处于起步阶段，需要进一步的特征描述和评估。
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本文引用的文献
1
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.2008 年全球癌症负担估计值：GLOBOCAN 2008。
Int J Cancer. 2010 Dec 15;127(12):2893-917. doi: 10.1002/ijc.25516.
2
MicroRNA expression profiling of exfoliated colonocytes isolated from feces for colorectal cancer screening.从粪便中分离脱落的结肠细胞进行大肠癌筛查的 microRNA 表达谱分析。
Cancer Prev Res (Phila). 2010 Nov;3(11):1435-42. doi: 10.1158/1940-6207.CAPR-10-0036. Epub 2010 Oct 19.
3
A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells.一种外排蛋白 5 的基因缺陷将前体 microRNAs 困在癌细胞的核内。
Cancer Cell. 2010 Oct 19;18(4):303-15. doi: 10.1016/j.ccr.2010.09.007.
4
Specific alterations of microRNA transcriptome and global network structure in colorectal carcinoma after cetuximab treatment.结直肠癌患者接受西妥昔单抗治疗后 microRNA 转录组和整体网络结构的特定改变。
Mol Cancer Ther. 2010 Dec;9(12):3396-409. doi: 10.1158/1535-7163.MCT-10-0137. Epub 2010 Sep 29.
5
Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis.体液循环 microRNA：癌症诊断和预后的新潜在生物标志物。
Cancer Sci. 2010 Oct;101(10):2087-92. doi: 10.1111/j.1349-7006.2010.01650.x. Epub 2010 Jul 7.
6
Relevance of miR-21 and miR-143 expression in tissue samples of colorectal carcinoma and its liver metastases.miR-21和miR-143表达在结直肠癌及其肝转移组织样本中的相关性
Cancer Genet Cytogenet. 2010 Jul 15;200(2):154-60. doi: 10.1016/j.cancergencyto.2010.04.015.
7
Role of primary miRNA polymorphic variants in metastatic colon cancer patients treated with 5-fluorouracil and irinotecan.原发性 miRNA 多态性变异在接受氟尿嘧啶和伊立替康治疗的转移性结直肠癌患者中的作用。
Pharmacogenomics J. 2011 Dec;11(6):429-36. doi: 10.1038/tpj.2010.58. Epub 2010 Jun 29.
8
Fecal MicroRNAs as novel biomarkers for colon cancer screening.粪便 microRNAs 作为结肠癌筛查的新型生物标志物。
Cancer Epidemiol Biomarkers Prev. 2010 Jul;19(7):1766-74. doi: 10.1158/1055-9965.EPI-10-0027. Epub 2010 Jun 15.
9
Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells.miR-215 介导骨肉瘤和结肠癌耐药的分子机制。
Mol Cancer. 2010 Apr 30;9:96. doi: 10.1186/1476-4598-9-96.
10
Molecular detection of colorectal neoplasia.结直肠肿瘤的分子检测。
Gastroenterology. 2010 Jun;138(6):2127-39. doi: 10.1053/j.gastro.2010.01.055.
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