Division of STD Prevention, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, E-02, Atlanta, GA, 30333, USA,
Curr Infect Dis Rep. 2011 Apr;13(2):196-204. doi: 10.1007/s11908-011-0169-9.
The development of resistance to multiple antibiotics has limited treatment options for gonorrhea in many countries. Currently, the Centers for Disease Control and Prevention only recommend cephalosporin antibiotics for treatment of uncomplicated gonorrhea. Although the cephalosporins remain effective, the demonstrated ability of Neisseria gonorrhoeae to develop resistance has raised concerns about the possibility of multidrug-resistant N. gonorrhoeae strains, which include cephalosporin resistance. This article provides a review of global trends in cephalosporin susceptibility among gonococcal isolates, recent findings that deepen our understanding of genetic mechanisms of resistance, and the public health and clinical implications of the potential emergence of cephalosporin-resistant gonorrhea.
耐多种抗生素的出现限制了许多国家淋病的治疗选择。目前，疾病预防控制中心仅推荐头孢菌素类抗生素治疗单纯淋病。尽管头孢菌素类仍有效，但淋病奈瑟菌产生耐药性的能力已引起人们对可能出现耐多药淋病奈瑟菌菌株（包括头孢菌素耐药性）的担忧。本文综述了全球淋病奈瑟菌分离株对头孢菌素类药物敏感性的趋势、加深我们对耐药遗传机制的理解的最新发现，以及头孢菌素耐药淋病出现的公共卫生和临床意义。
