Swedish Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Microbiology, Orebro University Hospital, Orebro, Sweden.
Euro Surveill. 2010 Nov 25;15(47):19721. doi: 10.2807/ese.15.47.19721-en.
Neisseria gonorrhoeae has developed resistance to most of the available therapeutic antimicrobials. The susceptibility to extended-spectrum cephalosporins, the last remaining first-line treatment option, is decreasing globally. This report describes the first two cases outside Japan of verified gonorrhoea clinical failures using internationally recommended first-line cefixime treatment. Enhanced awareness and more frequent follow-up examination, test-of-cure and appropriate verification/falsification of presumed clinical treatment failures, involving several clinical and laboratory parameters should be strongly emphasised worldwide.
淋病奈瑟菌已经对大多数现有的治疗性抗菌药物产生了耐药性。对扩展谱头孢菌素的敏感性（最后剩下的一线治疗选择）正在全球范围内下降。本报告描述了在日本以外的地方，首次使用国际推荐的一线头孢克肟治疗证实的淋病临床失败的两例病例。全世界都应该强烈强调提高认识和更频繁地进行随访检查、治愈试验以及对疑似临床治疗失败进行适当的验证/否定，涉及多个临床和实验室参数。
