Jakubczyk D
Kliniki Endokrynologii Akademii Medycznej, Białymstoku.
Rocz Akad Med Bialymst (1989). 1990;35-36:21-42.
In 56 patients with simple obesity blood glucose and insulin levels were assessed under fasting conditions and after oral glucose tolerance test. Besides, several lipid metabolism parameters like triglycerides, HDL--and LDL--cholesterol were estimated, too. Direct relationship was found between the impairment of glucose tolerance and the duration of obesity and the overweight. Obese persons with higher overweight and an average duration of obesity exhibited fasting hyperinsulinemia. Irrespective of the overweight magnitude and the degree of glucose tolerance impairment a more pronounced insulin reaction to glucose was observed. The same was found in the groups of persons with the history of obesity not exceeding 15 years. Moreover, in the group of obese persons with normal glucose tolerance, in those with overweight reaching 70% and with short and moderate duration of. Fasting obese hyperinsulinemic persons showed reduced concentration of HDL--obesity the levels of triglycerides were found to be elevated.
对56例单纯性肥胖患者在空腹状态下以及口服葡萄糖耐量试验后评估血糖和胰岛素水平。此外，还评估了甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇等几种脂质代谢参数。发现糖耐量损害与肥胖持续时间及超重之间存在直接关系。超重程度较高且肥胖平均持续时间较长的肥胖者表现出空腹高胰岛素血症。无论超重程度和糖耐量损害程度如何，均观察到对葡萄糖的胰岛素反应更为明显。在肥胖病史不超过15年的人群组中也发现了同样情况。此外，在糖耐量正常的肥胖人群组中，超重达到70%且肥胖持续时间短至中等的人群中，空腹肥胖高胰岛素血症患者的高密度脂蛋白浓度降低，甘油三酯水平升高。
