University of Manitoba, Winnipeg, Canada.
Osteoporos Int. 2012 Jan;23(1):391-7. doi: 10.1007/s00198-011-1592-3. Epub 2011 Mar 2.
Most patients designated as high risk of fracture using fracture risk assessment tool (FRAX) with femoral neck bone mineral density (BMD) (i.e., 10-year major osteoporotic fracture probability exceeding 20% or hip fracture exceeding 3%) have one or more T-scores in the osteoporotic range; conversely, almost no high risk patients have normal T-scores at all bone mineral density measurement sites.
We determined the agreement between a FRAX designation of high risk of fracture [defined as 10-year major osteoporotic fracture probability (≥ 20%) or hip fracture probability (≥ 3%)] and the WHO categorizations of bone mineral density according to T-score.
Ten-year FRAX probabilities calculated with femoral neck BMD were derived using both Canadian and US white tools for a large clinical cohort of 36,730 women and 2,873 men age 50 years and older from Manitoba, Canada. Individuals were classified according to FRAX fracture probability and BMD T-scores alone.
Most individuals designated by FRAX as high risk of major osteoporotic fracture had a T-score in the osteoporotic range at one or more BMD measurement sites (85% with Canadian tool and 83% with US white tool). The majority of individuals deemed at high risk of hip fracture had one or more T-scores in the osteoporotic range (66% with Canadian tool and 64% with US white tool). Conversely, there were extremely few individuals (<1%) who were at high risk of major osteoporotic or hip fracture with normal T-scores at all BMD measurement sites.
A FRAX designation of high risk of fracture is usually associated with a densitometric diagnosis of osteoporosis.
大多数使用股骨颈骨密度（BMD）的骨折风险评估工具（FRAX）被指定为骨折高风险的患者（即 10 年主要骨质疏松性骨折概率超过 20%或髋部骨折超过 3%），其一个或多个骨密度测量部位的 T 评分处于骨质疏松范围内；相反，几乎没有高风险患者的所有骨密度测量部位的 T 评分都正常。
我们确定了 FRAX 骨折高风险的指定（定义为 10 年主要骨质疏松性骨折概率（≥20%）或髋部骨折概率（≥3%））与根据 T 评分的世界卫生组织（WHO）骨密度分类之间的一致性。
使用加拿大和美国的白人工具，从加拿大马尼托巴省的 36730 名女性和 2873 名 50 岁及以上的男性中得出了基于股骨颈 BMD 的 10 年 FRAX 概率。个体根据 FRAX 骨折概率和 BMD T 评分单独进行分类。
大多数被 FRAX 指定为主要骨质疏松性骨折高风险的个体在一个或多个 BMD 测量部位的 T 评分处于骨质疏松范围内（加拿大工具为 85%，美国白人工具为 83%）。大多数被认为髋部骨折高风险的个体在一个或多个骨密度测量部位的 T 评分处于骨质疏松范围内（加拿大工具为 66%，美国白人工具为 64%）。相反，在所有 BMD 测量部位的 T 评分都正常的情况下，属于高风险的主要骨质疏松性或髋部骨折的个体非常少（<1%）。
FRAX 骨折高风险的指定通常与骨质疏松症的密度测定诊断相关。
