Chair and Department of Family Medicine, Poznan University of Medical Sciences, Poland.
Endokrynol Pol. 2011 Jan-Feb;62(1):45-7.
Anorexia nervosa (AN) has in recent years become considerably more common. The disease primarily affects girls and young women, and also boys and young men. AN is a risk factor for secondary osteoporosis. AN-related metabolic disturbances lead to diminished bone quality and increased risk of fractures. The consequences of low energy fractures are the main causes of death in women with AN. Hormonal disturbances (e.g. hypoestrogenism, increased levels of ghrelin and Y peptide, changes in leptin and endocannabinoid levels), as well as the mechanisms involved in bone resorption (RANK/RANKL/OPG), are considered to be of great importance for anorectic bone quality. The risk of osteoporotic, non-vertebral fractures in AN patients is significantly higher than in healthy women. An improvement of bone mineral density is possible after substantial body mass increase. Weight loss, in conjunction with a well-balanced, controlled diet, is the key to correct peak bone mass levels, and diminishes the risk of osteoporosis with its consequence of low energy bone fractures. (Pol J Endocrinol 2011; 62 (1): 45-47).
神经性厌食症（AN）近年来变得更为常见。这种疾病主要影响女孩和年轻女性，也会影响男孩和年轻男性。AN 是继发性骨质疏松症的一个风险因素。与 AN 相关的代谢紊乱会导致骨质量下降和骨折风险增加。低能量骨折的后果是 AN 女性死亡的主要原因。激素紊乱（例如，雌激素减少、胃饥饿素和 Y 肽水平增加、瘦素和内源性大麻素水平变化）以及涉及骨吸收的机制（RANK/RANKL/OPG）被认为对厌食性骨质量非常重要。AN 患者发生骨质疏松性、非椎体骨折的风险明显高于健康女性。在体重显著增加后，骨矿物质密度可能会改善。减肥与均衡、控制饮食相结合是达到理想峰值骨量水平的关键，可降低骨质疏松症及其导致的低能量骨折风险。（波兰内分泌学会杂志 2011；62（1）：45-47）。
