Husain Aliabbas A, Kashyap Rajpal S, Kalorey Devanand R, Warke Shubangi R, Purohit Hemant J, Taori Girdhar M, Daginawal Hatim F
Biochemistry Research Laboratory, Central India Institute of Medical Sciences, 88/2 Bajaj Nagar, Nagpur 440 010, India.
Indian J Exp Biol. 2011 Jan;49(1):7-10.
BCG is the only vaccine presently available against tuberculosis but it is estimated to prevent only 5% of the all potentially vaccine-preventable deaths due to Tuberculosis. Keeping these in view the present study has been undertaken to evaluate the efficacy of BCG and the effect of repeat dose of BCG on antimycobacterial humoral response in mouse model. To improve BCG immunogenicity, specific anti-mycobacterial immune responses (anti-BCG titre and total IgG level) were evaluated in mouse model using boost immunization protocols with the BCG vaccine. Mice induced with a repeat dose of BCG showed an increased anti mycobacterial humoral response, which gradually declined few weeks after single dose of BCG administration. The results suggest improved efficacy of BCG vaccine by giving repeat dose of BCG that can enhance the level of immunoprotection against tuberculosis as opposed to a single BCG dose.
卡介苗是目前唯一可用于预防结核病的疫苗，但据估计，它仅能预防所有潜在的可通过疫苗预防的结核病死亡病例中的5%。鉴于此，本研究旨在评估卡介苗的疗效以及重复接种卡介苗对小鼠模型抗分枝杆菌体液反应的影响。为提高卡介苗的免疫原性，在小鼠模型中使用卡介苗疫苗加强免疫方案评估了特异性抗分枝杆菌免疫反应（抗卡介苗滴度和总IgG水平）。重复接种卡介苗的小鼠表现出抗分枝杆菌体液反应增强，在单次接种卡介苗几周后，这种反应逐渐下降。结果表明，重复接种卡介苗可提高卡介苗疫苗的疗效，与单次接种卡介苗相比，重复接种可增强对结核病的免疫保护水平。
