Ogoina Dimie, Onyemelukwe Geoffrey C, Musa Bolanle O P, Babadoko Aliyu
Immunology unit, Department of Medicine, Ahmadu Bello University Teaching Hospital (ABUTH), Zaria, Nigeria,
J Int Assoc Physicians AIDS Care (Chic). 2011 Jan-Feb;10(1):43-8. doi: 10.1177/1545109710387300.
BACKGROUND/OBJECTIVES: Studies on human herpesvirus 8 (HHV8) infection in patients with AIDS-associated Kaposi sarcoma (AIDS-KS), from Nigeria are lacking. We examined the seroprevalence of HHV8 infection in patients with AIDS-KS presenting to Ahmadu Bello University Teaching Hospital (ABUTH), Zaria, Nigeria, and also described their clinical presentation.
A total of 20 (11 males and 9 females) histologically confirmed adults with AIDS-KS were recruited consecutively in 2007. The clinical types of lesions, associated diseases, and the AIDS clinical trial group staging of AIDS-KS were noted. Anti-lytic HHV8 antibodies were determined by enzyme-linked immunosorbent assay (ELISA).
Kaposi sarcoma skin lesions were diverse but mostly nodules (19 cases) and papules (16). Majority (18 cases) had poor risk AIDS-KS, with 10 (50%) patients having concomitant opportunistic infections and 3 (15%) patients having generalized skin lesions. Females had a more severe disease. Seventeen patients (85%) were HHV8-seropositive.
AIDS-KS is associated with high HHV8 infection and presents with a variety of skin manifestations that are often aggressive, advanced, and worse in females.
背景/目的：尼日利亚缺乏对艾滋病相关卡波西肉瘤（AIDS-KS）患者进行的人类疱疹病毒8型（HHV8）感染研究。我们调查了在尼日利亚扎里亚市阿马杜·贝洛大学教学医院（ABUTH）就诊的AIDS-KS患者中HHV8感染的血清流行率，并描述了他们的临床表现。
2007年连续招募了20名（11名男性和9名女性）经组织学确诊的成年AIDS-KS患者。记录病变的临床类型、相关疾病以及AIDS-KS的艾滋病临床试验组分期。通过酶联免疫吸附测定（ELISA）检测抗裂解性HHV8抗体。
卡波西肉瘤皮肤病变多样，但大多为结节（19例）和丘疹（16例）。大多数（18例）患者为高危AIDS-KS，10名（50%）患者伴有机会性感染，3名（15%）患者有全身性皮肤病变。女性病情更严重。17名患者（85%）HHV8血清学呈阳性。
AIDS-KS与HHV8高感染率相关，表现为多种皮肤表现，通常具有侵袭性、病情进展且女性患者情况更糟。
