Van Dyke D C, Lang D J, van Duyne S, Heide F, Chang H J
Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City 52242.
Pediatrics. 1990 Jan;85(1):79-84.
Cell therapy, the administration of freeze-dried or lyophilized cells derived from fetal tissue of animals, has been suggested and accepted by some parents as a treatment for Down syndrome. Such therapy regimens have been purported to ameliorate dysmorphic features and to result in improvement in IQ, motor skills, social behavior, height, language, and memory. Interest in this therapy continues despite a lack of empirical support for its use and its illegality in the United States. In this study, 190 subjects of whom 21 had received cell therapy (from sources external to this study) were studied for 18 variables in the areas of growth, motor development, cognitive development, and adaptive/social status. Comparing the cell-treated group with a control group matched for sex, age, socioeconomic status, and cardiac history showed no statistically significant differences for any of the developmental or growth variables measured. These findings fail to support continued claims of improved functioning following cell therapy in persons with Down syndrome.
细胞疗法，即给予源自动物胎儿组织的冻干或冻融细胞，已被一些家长提议并接受作为唐氏综合征的一种治疗方法。据称，此类治疗方案可改善畸形特征，并提高智商、运动技能、社交行为、身高、语言和记忆力。尽管在美国缺乏对其使用的实证支持且该疗法属于非法，但对这种疗法的兴趣依然存在。在本研究中，对190名受试者进行了研究，其中21人接受了细胞疗法（来自本研究以外的来源），研究了生长、运动发育、认知发育和适应/社会状况等领域的18个变量。将接受细胞治疗的组与在性别、年龄、社会经济地位和心脏病史方面相匹配的对照组进行比较，结果显示，所测量的任何发育或生长变量均无统计学上的显著差异。这些发现无法支持唐氏综合征患者接受细胞治疗后功能持续改善的说法。
