Stomper P C, Van Voorhis B J, Ravnikar V A, Meyer J E
Department of Radiology, Roswell Park Memorial Institute, School of Medicine and Biomedical Science, SUNY, Buffalo 14263.
Radiology. 1990 Feb;174(2):487-90. doi: 10.1148/radiology.174.2.2136958.
A retrospective study of radiologic findings from 50 postmenopausal women who underwent hormone replacement therapy was performed to determine the frequency and distribution of changes in the screen-film mammographic appearance of breast tissue between pretreatment and posttreatment mammography. Twelve (24%) of the women developed increased parenchymal density during a median follow-up of 18 months (range, 6-39 months). Mammographic changes included diffuse increase in density in seven (14%) of the women; increased multifocal, asymmetric densities in two (4%); and cyst formation in three (6%). A greater percentage of women who received estrogen-progesterone replacement (26%, 10 of 38) demonstrated changes than those who received estrogen alone (17%, two of 12), but the difference was not statistically significant. The authors conclude that benign increases in mammographic density associated with postmenopausal hormone replacement therapy are not uncommon, and they suggest that the serial changes observed in some women may diminish the sensitivity of mammography for the earlier detection of breast cancer.
对50名接受激素替代疗法的绝经后女性的放射学检查结果进行了一项回顾性研究，以确定治疗前和治疗后乳房X线摄影中乳腺组织影像表现变化的频率和分布。在中位随访18个月（范围6 - 39个月）期间，12名（24%）女性出现实质密度增加。乳房X线摄影变化包括7名（14%）女性密度弥漫性增加；2名（4%）女性多灶性、不对称密度增加；3名（6%）女性出现囊肿形成。接受雌激素 - 孕激素替代治疗的女性（26%，38名中的10名）出现变化的比例高于仅接受雌激素治疗的女性（17%，12名中的2名），但差异无统计学意义。作者得出结论，绝经后激素替代疗法相关的乳房X线摄影密度良性增加并不罕见，他们还指出，在一些女性中观察到的系列变化可能会降低乳房X线摄影对早期乳腺癌检测的敏感性。
