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原发性醛固酮增多症的诊断与治疗。

Diagnosis and treatment of primary aldosteronism.

机构信息

DMCS Gino Patrassi-Clinica Medica 4, University of Padua, Padua, Italy.

出版信息

Rev Endocr Metab Disord. 2011 Mar;12(1):27-36. doi: 10.1007/s11154-011-9162-8.

DOI:10.1007/s11154-011-9162-8
PMID:21369868
Abstract

Primary aldosteronism involves more than 11% of hypertensive patients who are referred to specialized centers for the diagnosis and treatment of hypertension. If not diagnosed early it causes an excess damage to the heart, vessels and kidney, which translates into an cardiovascular events. Since these ominous consequences can be corrected with a timely diagnosis and an appropriate therapy, physicians should exercise a high degree of alert concerning the possibility that primary aldosteronism is present in hypertensive patients. The purpose of this review is to provide up-dated information on the strategy for case detection, the subtype differentiation and the management of primary aldosteronism.

摘要

原发性醛固酮增多症涉及到超过 11%的高血压患者,他们被转介到专门的中心进行高血压的诊断和治疗。如果早期没有得到诊断,它会导致心脏、血管和肾脏的过度损伤,进而导致心血管事件。由于这些严重后果可以通过及时诊断和适当的治疗来纠正,因此医生应该高度警惕高血压患者中是否存在原发性醛固酮增多症。本文旨在提供关于原发性醛固酮增多症病例检测策略、亚型分化和治疗的最新信息。

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本文引用的文献

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Aldosterone synthase inhibition with LCI699: a proof-of-concept study in patients with primary aldosteronism.用 LCI699 抑制醛固酮合酶:原发性醛固酮增多症患者的概念验证研究。
Hypertension. 2010 Nov;56(5):831-8. doi: 10.1161/HYPERTENSIONAHA.110.157271. Epub 2010 Sep 13.
2
The aldosterone-renin ratio based on the plasma renin activity and the direct renin assay for diagnosing aldosterone-producing adenoma.基于血浆肾素活性和直接肾素测定的醛固酮-肾素比值在醛固酮瘤诊断中的应用。
J Hypertens. 2010 Sep;28(9):1892-9. doi: 10.1097/HJH.0b013e32833d2192.
3
Aldosterone causes DNA strand breaks and chromosomal damage in renal cells, which are prevented by mineralocorticoid receptor antagonists.
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Int J Exp Pathol. 2018 Apr;99(2):77-86. doi: 10.1111/iep.12267. Epub 2018 Apr 17.
4
Comparison of C-arm computed tomography and on-site quick cortisol assay for adrenal venous sampling: A retrospective study of 178 patients.C 臂 CT 与现场快速皮质醇检测在肾上腺静脉取血中的比较:178 例患者的回顾性研究。
Eur Radiol. 2017 Dec;27(12):5006-5014. doi: 10.1007/s00330-017-4930-9. Epub 2017 Jul 4.
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J Hum Hypertens. 2017 Oct;31(10):627-632. doi: 10.1038/jhh.2017.38. Epub 2017 May 25.
6
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Sci Rep. 2016 Nov 23;6:37143. doi: 10.1038/srep37143.
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