Boyce S T
Department of Surgical Research, University of Cincinnati, OH.
Methods Mol Med. 1999;18:365-89. doi: 10.1385/0-89603-516-6:365.
Objectives for dermal-epidermal skin substitutes for treatment of acute and chronic wounds include, but are not limited to: increased availability; stimulation of wound healing by transplantation of parenchymal cells; regulation of wound healing responses; and, predictable composition and efficacy to reduce mortality and morbidity. Particularly, the importance of including a cellular component has been demonstrated in experimental grafts of cells and biopolymers (1-7). Transplanted cells may include normal, nontransformed populations isolated for primary culture, or genetically modified cells to deliver specific gene products of therapeutic interest (8-10). Nontransformed cells may include autologous, allogeneic, or chimeric populations within composite grafts. A variety of approaches are directed toward repair of skin wounds by restoration of the functional anatomy and physiology of skin.
用于治疗急慢性伤口的真皮-表皮皮肤替代物的目标包括但不限于：提高可用性；通过实质细胞移植刺激伤口愈合；调节伤口愈合反应；以及具有可预测的成分和功效以降低死亡率和发病率。特别地，在细胞和生物聚合物的实验性移植中已证明包含细胞成分的重要性(1-7)。移植的细胞可以包括为原代培养分离的正常、未转化群体，或用于递送具有治疗意义特定基因产物的基因修饰细胞(8-10)。未转化细胞可以包括复合移植物中的自体、同种异体或嵌合群体。多种方法旨在通过恢复皮肤的功能解剖结构和生理功能来修复皮肤伤口。
