Gillings School of Global Public Health, University of Carolina, Chapel Hill, NC, USA.
Int J Gynecol Cancer. 2010 Dec;20(9):1593-6.
Human papillomavirus (HPV) prevalence and type distribution were estimated among 90 female sex workers (FSWs) aged 18 to 58 years in Antananarivo, Madagascar.
A total of 90 FSWs aged 18 to 58 years in Antananarivo, Madagascar, were included in this study. Information on sexual and behavioral characteristics was obtained via a questionnaire. Exfoliated cervical cell specimens were collected for conventional cytologic examination and HPV DNA testing by polymerase chain reaction. The prevalence rates of HPV DNA and their corresponding 95% confidence intervals were stratified into the following 3 age groups: younger than 25, 25 to 34, and 35 years or older. To assess the association between HPV DNA positivity and sociodemographic and sexual behavioral factors, age-adjusted odds ratios and 95% confidence intervals were calculated using unconditional logistic regression.
The HPV prevalence in exfoliated cervical cell specimens was 36.7%. The most common HPV types found were HPV-52 (11.1%), HPV-31 and -39 (each at 5.6%), and HPV-16 and -83 (each at 3.3%). The prevalence of low-grade squamous intraepithelial lesions was 3.3%, and that of atypical squamous cells of undetermined significance was 18.9%. No high-grade lesion was found. Although associations were imprecise, the HPV prevalence was higher among women who reported younger age at the first intercourse, contraceptive use, a history of cervical lesions, and no history of condom use.
The prevalence rates of HPV and cervical lesions among FSWs in Madagascar appear higher than among FSW populations from other African countries with a relatively higher population-based prevalence of human immunodeficiency virus infection.
在马达加斯加首都塔那那利佛，对 90 名 18 至 58 岁的女性性工作者（FSW）进行了人乳头瘤病毒（HPV）流行率和型别分布的估计。
在马达加斯加首都塔那那利佛，共纳入 90 名 18 至 58 岁的 FSW。通过问卷获取性和行为特征信息。采集宫颈脱落细胞标本进行常规细胞学检查和 HPV DNA 聚合酶链反应检测。HPV DNA 的流行率及其相应的 95%置信区间按以下 3 个年龄组分层：<25 岁、25-34 岁和 35 岁或以上。为评估 HPV DNA 阳性与社会人口学和性行为因素之间的关系，使用非条件逻辑回归计算年龄调整后的比值比及其 95%置信区间。
宫颈脱落细胞标本中 HPV 的流行率为 36.7%。最常见的 HPV 类型为 HPV-52（11.1%）、HPV-31 和 -39（各 5.6%）以及 HPV-16 和 -83（各 3.3%）。低度鳞状上皮内病变的流行率为 3.3%，非典型鳞状细胞意义不明确的流行率为 18.9%。未发现高级别病变。尽管关联不精确，但首次性交年龄较小、使用避孕药具、有宫颈病变史和无避孕套使用史的女性 HPV 流行率较高。
马达加斯加 FSW 中的 HPV 和宫颈病变流行率似乎高于其他非洲国家的 FSW 人群，而这些国家的人群中艾滋病毒感染的流行率相对较高。
