钠平衡对单肾单夹肾性高血压大鼠心房利钠因子的影响。
Influence of sodium balance on atrial natriuretic factor in rats with one-kidney, one-clip renal hypertension.
作者信息
Lattion A L, Flückiger J P, Waeber B, Nussberger J, Aubert J F, Brunner H R
机构信息
Division of Hypertension, University Hospital, Lausanne, Switzerland.
出版信息
Experientia. 1990 Jan 15;46(1):69-72. doi: 10.1007/BF01955419.
The influence of sodium intake on the gene expression and circulating levels of atrial natriuretic factor (ANF) was investigated in unanesthetized rats with one-kidney, one-clip renal hypertension. After clipping, the rats were maintained for 3 weeks either on a salt-deficient (n = 11) or a regular-sodium diet (n = 10). Animals which had received the regular-sodium diet exhibited significantly higher ANF mRNA levels in their right and left atria than salt-restricted animals, whereas there was no significant difference in plasma ANF levels.
在单肾单夹肾性高血压未麻醉大鼠中，研究了钠摄入量对心房利钠因子（ANF）基因表达和循环水平的影响。夹闭后，将大鼠维持在缺盐饮食（n = 11）或正常钠饮食（n = 10）下3周。接受正常钠饮食的动物，其左右心房中的ANF mRNA水平显著高于限盐动物，而血浆ANF水平则无显著差异。
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