生酮饮食抑制哺乳动物雷帕霉素靶蛋白（mTOR）通路。
The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway.
机构信息
Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA.
出版信息
Epilepsia. 2011 Mar;52(3):e7-11. doi: 10.1111/j.1528-1167.2011.02981.x. Epub 2011 Mar 3.
Abstract
The ketogenic diet (KD) is an effective treatment for epilepsy, but its mechanisms of action are poorly understood. We investigated the hypothesis that the KD inhibits mammalian target of rapamycin (mTOR) pathway signaling. The expression of pS6 and pAkt, markers of mTOR pathway activation, was reduced in hippocampus and liver of rats fed KD. In the kainate model of epilepsy, KD blocked the hippocampal pS6 elevation that occurs after status epilepticus. Because mTOR signaling has been implicated in epileptogenesis, these results suggest that the KD may have anticonvulsant or antiepileptogenic actions via mTOR pathway inhibition.
摘要
生酮饮食（KD）是一种有效的癫痫治疗方法，但它的作用机制尚不清楚。我们研究了 KD 抑制哺乳动物雷帕霉素靶蛋白（mTOR）通路信号的假说。在 KD 喂养的大鼠的海马体和肝脏中，mTOR 通路激活标志物 pS6 和 pAkt 的表达减少。在癫痫的海人酸模型中，KD 阻断了癫痫持续状态后海马体 pS6 的升高。由于 mTOR 信号转导与癫痫发生有关，这些结果表明 KD 可能通过抑制 mTOR 通路发挥抗惊厥或抗癫痫作用。
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3
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4
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Epilepsia. 2008 Nov;49 Suppl 8:94-6. doi: 10.1111/j.1528-1167.2008.01847.x.
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