Torti Dorothea C, Brennick Jeoffry B, Storm Craig A, Dinulos James G H
Section of Dermatology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA.
Pediatr Dermatol. 2011 Sep-Oct;28(5):561-7. doi: 10.1111/j.1525-1470.2011.01239.x. Epub 2011 Mar 3.
Spitz nevi are small dome-shaped nodules that sometimes arise in areas of preexisting hyperpigmentation, such as a speckled lentiginous nevus (nevus spilus), where they present a diagnostic dilemma. We report clinical, histopathological, and molecular findings of two cases of multiple Spitz nevi arising in a speckled lentiginous nevus. We used immunohistochemistry to assess expression of Ki-67, epidermal growth factor receptor, vascular endothelial growth factor, and RelA in two cases of Spitz nevi arising in a speckled lentiginous nevus. We observed rare staining for the proliferative marker Ki-67, but positive staining for the growth and antiapoptotic factors epidermal growth factor receptor, vascular endothelial growth factor, and RelA. Characterization of the molecular phenotype of Spitz nevi arising in speckled lentiginous nevi may provide a useful adjunct to long-term monitoring in this rare but difficult clinical presentation.
斯皮茨痣是小的圆顶状结节，有时出现在先前存在色素沉着过度的区域，如斑点状雀斑样痣（斑痣），在这些部位它们会带来诊断难题。我们报告了两例发生在斑点状雀斑样痣中的多发性斯皮茨痣的临床、组织病理学和分子学发现。我们采用免疫组织化学方法评估了两例发生在斑点状雀斑样痣中的斯皮茨痣中Ki-67、表皮生长因子受体、血管内皮生长因子和RelA的表达情况。我们观察到增殖标志物Ki-67染色罕见，但生长和抗凋亡因子表皮生长因子受体、血管内皮生长因子和RelA染色呈阳性。对发生在斑点状雀斑样痣中的斯皮茨痣的分子表型进行特征分析，可能为这种罕见但临床棘手的表现的长期监测提供有用的辅助手段。
