Isabel Zhu Y, Fitzpatrick James E
Department of Dermatology, University of Colorado Health Science Center, Aurora, CO 80045-0510, USA.
J Cutan Pathol. 2006 Jan;33(1):33-7. doi: 10.1111/j.0303-6987.2006.00420.x.
CD117, the receptor for kit-ligand, which is a growth factor for melanocyte migration and proliferation, has shown differential staining in various benign and malignant melanocytic lesions. The purpose of this study is to compare CD117 immunohistological staining in Spitz nevus versus malignant melanoma, to determine whether CD117 can aid in the diagnosis of these two lesions.
CD-117 immunohistological staining was performed in 22 clinically and pathologically diagnosed pigmented lesions including 9 cases of Spitz nevus, 10 cases of primary MM and 3 cases of metastatic melanoma.
There was no significant difference in CD117 staining in either epidermis or dermis between Spitz nevi and primary melanomas. However staining of metastatic melanomas is less than dermal staining of primary MM and Spitz nevus.
CD117 is unlikely a useful diagnostic tool in differentiating Spitz nevus from primary MM. On the other hand, CD 117 may be useful in differentiating metastatic melanoma from primary melanoma in patients who had a history of melanoma and who present with new dermal lesions.
CD117是干细胞生长因子受体，该生长因子可促进黑素细胞迁移和增殖，在各种良性和恶性黑素细胞病变中呈现不同的染色情况。本研究旨在比较Spitz痣与恶性黑色素瘤中CD117的免疫组织化学染色，以确定CD117是否有助于这两种病变的诊断。
对22例经临床和病理诊断的色素沉着病变进行CD-117免疫组织化学染色，其中包括9例Spitz痣、10例原发性黑色素瘤和3例转移性黑色素瘤。
Spitz痣与原发性黑色素瘤的表皮或真皮中CD117染色无显著差异。然而，转移性黑色素瘤的染色低于原发性黑色素瘤和Spitz痣的真皮染色。
CD117不太可能作为区分Spitz痣与原发性黑色素瘤的有用诊断工具。另一方面，对于有黑色素瘤病史且出现新的皮肤病变的患者，CD117可能有助于区分转移性黑色素瘤与原发性黑色素瘤。
