短篇通讯：加纳抗逆转录病毒治疗项目中晚期 HIV 感染者中隐球菌抗原血症的低血清阳性率。
Short Communication: Low seroprevalence of cryptococcal antigenaemia in patients with advanced HIV infection enrolling in an antiretroviral programme in Ghana.
机构信息
Department of Infection & Travel Medicine, The James Cook University Hospital, Middlesbrough, UK.
出版信息
Trop Med Int Health. 2011 Jan;16(1):53-6. doi: 10.1111/j.1365-3156.2010.02683.x. Epub 2010 Nov 10.
OBJECTIVES
To determine the prevalence of cryptococcal antigenaemia in a clinic population with advanced HIV infection, with a view to giving antifungal therapy to those testing positive.
METHODS
Serum samples from adults with CD4 count <100 cells/mm(3) presenting to a large HIV clinic in Kumasi, Ghana, were tested retrospectively for cryptococcal antigenaemia using a latex agglutination assay, and clinical and demographic data extracted from case notes.
RESULTS
Of 92 samples tested, two were positive thus giving a prevalence of 2% (95% CI, 0-5.2%).
CONCLUSIONS
The prevalence of cryptococcal antigenaemia in patients with advanced HIV infection enrolling in an antiretroviral programme appears to be low in Kumasi, suggesting that the value of routine testing of outpatients diagnosed with advanced HIV infection may be limited in this population.
目的
在患有晚期 HIV 感染的临床人群中确定隐球菌抗原血症的患病率，以便对检测呈阳性的患者进行抗真菌治疗。
方法
回顾性地使用乳胶凝集检测法检测加纳库马西一家大型 HIV 诊所中 CD4 计数<100 个细胞/mm3的成人的血清样本是否存在隐球菌抗原血症，并从病历中提取临床和人口统计学数据。
结果
在检测的 92 个样本中，有两个呈阳性，因此患病率为 2%（95%CI，0-5.2%）。
结论
在接受抗逆转录病毒方案的晚期 HIV 感染患者中，隐球菌抗原血症的患病率似乎较低，这表明在该人群中，对诊断为晚期 HIV 感染的门诊患者进行常规检测的价值可能有限。
Zotero 插件