Department of Medicine, Temple University, Philadelphia, PA 19140, USA.
Arthritis Res Ther. 2011 Feb 28;13(1):202. doi: 10.1186/ar3206.
Systemic lupus erythematosus is a multifactorial autoimmune disease with an as yet unknown etiopathogenesis. It is widely thought that self-immunization in systemic lupus is driven by defective clearance of dead and dying cells. In lupus patients, large numbers of apoptotic cells accumulate in various tissues including germinal centers. In the present review, we discuss the danger signals released by apoptotic cells, their triggering of inflammatory responses, and the breakdown of B-cell tolerance. We also review the pathogenic role of apoptotic cell clearance in systemic lupus erythematosus.
系统性红斑狼疮是一种多因素自身免疫性疾病，其发病机制尚不清楚。人们普遍认为，系统性红斑狼疮中的自身免疫是由清除死亡和垂死细胞的功能缺陷驱动的。在狼疮患者中，大量凋亡细胞积聚在包括生发中心在内的各种组织中。在本综述中，我们讨论了凋亡细胞释放的危险信号、它们引发炎症反应的机制以及 B 细胞耐受的破坏。我们还回顾了凋亡细胞清除在系统性红斑狼疮中的致病作用。
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