Chikenji Takako, Berger Richard A, Fujimiya Mineko, Suzuki Daisuke, Tsubota Sadako, An Kai-Nan
Orthopedic Biomechanics Laboratory, Division of Orthopedic Research, Mayo Clinic, Rochester, MN 55905, USA.
J Hand Surg Am. 2011 Mar;36(3):406-12. doi: 10.1016/j.jhsa.2010.11.050.
To examine the distribution of encapsulated nerve endings called mechanoreceptors in the human distal interphalangeal (DIP) joint and surrounding structures.
We processed 12 right index finger DIP joints and surrounding structures from fresh cadavers for immunohistochemistry of the anti-protein gene product 9.5 (PGP9.5) and silver staining to detect encapsulated nerve endings. Serial transverse sections were cut throughout the whole specimen and divided into 3 regions along the longitudinal axis: distal, middle, and proximal. Each of the transverse sections was partitioned into dorsal capsule (DC), radial capsule (RC), ulnar capsule (UC), volar plate (VP), and radial and ulnar assemblage nuclei (RAN and UAN); the RAN and UAN are located on both the radial and ulnar side of the VP. The C3 pulley contained the proximal region of the RAN and UAN, whereas the A5 pulley contained the middle and distal. The accessory collateral ligament contained all the regions of the RAN and UAN. We analyzed and compared the density of encapsulated nerve endings among the 18 different regions.
According to the modified Freeman and Wyke classification, we identified type I (eg, Ruffini-like endings) and type II (eg, Pacini-like endings) nerve endings. The density of type II nerve endings in the proximal region of the RAN and UAN was considerably higher than that in the proximal region of the VP, RC, UC and DC, and that in the proximal region of the VP, RC, UC, and DC, respectively.
Our examination of the distribution of type I and type II nerve endings provides new information on the sensory systems of the DIP joints and surrounding structures.
研究被称为机械感受器的被囊神经末梢在人类远节指间（DIP）关节及周围结构中的分布情况。
我们对12个来自新鲜尸体的右手示指DIP关节及周围结构进行处理，用于抗蛋白基因产物9.5（PGP9.5）的免疫组织化学和银染色，以检测被囊神经末梢。在整个标本上切取连续的横切片，并沿纵轴分为3个区域：远侧、中间和近侧。每个横切片又被划分为背侧关节囊（DC）、桡侧关节囊（RC）、尺侧关节囊（UC）、掌板（VP）以及桡侧和尺侧联合核（RAN和UAN）；RAN和UAN位于VP的桡侧和尺侧。C3滑车包含RAN和UAN的近侧区域，而A5滑车包含其中间和远侧区域。副侧副韧带包含RAN和UAN的所有区域。我们分析并比较了18个不同区域中被囊神经末梢的密度。
根据改良的弗里曼和怀克分类法，我们识别出了I型（如类鲁菲尼小体）和II型（如类帕西尼小体）神经末梢。RAN和UAN近侧区域的II型神经末梢密度分别显著高于VP、RC、UC和DC近侧区域的相应密度，以及VP、RC、UC和DC近侧区域的密度。
我们对I型和II型神经末梢分布的研究为DIP关节及周围结构的感觉系统提供了新信息。
