Zeynep Kamil Women and Children's Health and Research Hospital, Turkey.
Eur J Obstet Gynecol Reprod Biol. 2011 May;156(1):101-4. doi: 10.1016/j.ejogrb.2010.12.025. Epub 2011 Mar 2.
Recurrent pregnancy loss is often defined as three or more consecutive pregnancy losses but there are no strict criteria for initiation of investigations after a miscarriage. We compared the frequency of uterine anomalies diagnosed by hysteroscopy following one, two and three or more miscarriages.
In our study 151 patients underwent diagnostic hysteroscopy following a missed or an incomplete abortion. Uterine septum, subseptum, arcuate uterus, and uterine hypoplasia are classified as congenital uterine anomalies and polyps, synechia, and submucous myomas are classified as acquired uterine abnormalities.
151 Patients were enrolled in the study. The pregnancy numbers of the patients varied between 1 and 12. Sixty nine (46%) of the patients had one miscarriage, 42 (28%) had two miscarriages and 40 (26%) had three or more miscarriages. Diagnostic hysteroscopy revealed normal uterine cavity in 61.1% of the patients, congenital uterine anomalies in 20.4% and acquired uterine pathologies in 18.5%. Among the congenital anomalies, 14 (9.3%) were uterine septum, 10 (6.6%) were subseptate uterus, 4 (2.6%) were arcuate uterus and 3 (1.9%) were uterine hypoplasia. Among acquired abnormalities 14 (9.3%) were uterine synechia, 12 (7.9%) were endometrial polyps, and 2 (1.3%) were submucous myoma. Among patients who had one miscarriage 64.1% had a normal uterine cavity, 18.2% had congenital abnormalities and 17.7% had acquired uterine pathologies. Of patients with two miscarriages, 52% had a normal uterine cavity, 21.9% had congenital anomalies and 26.1% had acquired uterine pathology. In the three or more miscarriage group, 58.4% had normal uterine cavity, 25.3% had congenital anomalies, and 16.3% had acquired uterine pathology. We did not find any statistically significant difference between the number of miscarriages and pathologic diagnostic hysteroscopy findings.
Post-abortion office hysteroscopy is a simple and efficient tool in the early diagnosis of congenital and acquired uterine pathologies. Diagnostic hysteroscopy can be performed after the first miscarriage in order to determine congenital and acquired uterine pathologies, with regard to the patient's age and anxiety level.
复发性流产通常定义为连续 3 次或 3 次以上的妊娠丢失,但对于流产后何时开始进行检查并无严格的标准。我们比较了因 1 次、2 次和 3 次或更多次流产后行宫腔镜检查诊断的子宫畸形的发生率。
在我们的研究中,151 例患者因稽留流产或不全流产行诊断性宫腔镜检查。子宫纵隔、双角子宫、弓形子宫和子宫发育不良被归类为先天性子宫畸形,息肉、粘连和黏膜下肌瘤被归类为获得性子宫异常。
151 例患者入组本研究。患者的妊娠次数为 1 至 12 次不等。69 例(46%)患者有 1 次流产,42 例(28%)患者有 2 次流产,40 例(26%)患者有 3 次或更多次流产。宫腔镜检查显示,61.1%的患者子宫腔正常,20.4%的患者存在先天性子宫畸形,18.5%的患者存在获得性子宫病变。在先天性畸形中,14 例(9.3%)为子宫纵隔,10 例(6.6%)为双角子宫,4 例(2.6%)为弓形子宫,3 例(1.9%)为子宫发育不良。在获得性异常中,14 例(9.3%)为子宫粘连,12 例(7.9%)为子宫内膜息肉,2 例(1.3%)为黏膜下肌瘤。有 1 次流产的患者中,64.1%的子宫腔正常,18.2%的患者存在先天性异常,17.7%的患者存在获得性子宫病变。有 2 次流产的患者中,52%的子宫腔正常,21.9%的患者存在先天性异常,26.1%的患者存在获得性子宫病变。在 3 次或更多次流产的患者中,58.4%的子宫腔正常,25.3%的患者存在先天性异常,16.3%的患者存在获得性子宫病变。我们没有发现流产次数和宫腔镜病理诊断结果之间有统计学意义上的差异。
流产后门诊宫腔镜检查是早期诊断先天性和获得性子宫疾病的一种简单有效的方法。为了确定先天性和获得性子宫疾病,可以在首次流产后进行宫腔镜检查,具体取决于患者的年龄和焦虑程度。