Department of Cardiovascular Surgery, Methodist DeBakey Heart & Vascular Center, Houston, TX, USA.
J Vasc Surg. 2011 Aug;54(2):364-9. doi: 10.1016/j.jvs.2010.12.063. Epub 2011 Mar 3.
Thoracic endograft placement has become an acceptable treatment alternative to open repair of the thoracic aorta. Cerebral embolization when manipulating the aortic arch during cardiac catheterization is well described, but the influence of thoracic endovascular aortic repair (TEVAR) on this event remains poorly studied. Our aim was to quantify the number of microembolic signals (MES) detected by transcranial Doppler (TCD) during different stages of TEVAR and correlate them with landing zones, subclavian revascularization, and postoperative morbidity and mortality.
TCD was used to monitor 20 patients during TEVAR for the treatment of thoracic aortic aneurysms (TAAs) in 17 (85%) patients, followed by three (15%) with chronic type B aortic dissection and one (5%) Crawford type I thoracoabdominal aortic aneurysm (TAAA). Imaging and medical parameters were entered into a combined database. TCD signals were recorded digitally for the entire case. MES, velocities, and pulsatility index values were entered into a combined database.
The total number of MES calculated for the diagnostic phase before TEVAR placement and during the treatment phase for all cases combined was 1081 and 1141, respectively. The highest MES counts were generated by the pigtail catheter placement during the diagnostic phase and by device placement during the treatment phase. Embolic count to right/left sides was equal overall. In the diagnostic phase, an average of nine MES were seen right/left, whereas during the treatment phase, 45 and 43 MES were seen, respectively, for right/left. A significant association was found between the total number of MES and postoperative stroke, transient ischemic attack (P = .0055), and death (P = .0053).
TCD can detect microemboli during TEVAR and is able to identify the procedural aspects most associated with cerebral microemboli.
胸主动脉腔内修复术(TEVAR)已成为治疗胸主动脉疾病的一种可接受的替代开放修复方法。在心脏导管术中操作主动脉弓时发生脑栓塞已有详细描述,但 TEVAR 对这一事件的影响仍研究甚少。我们的目的是量化经颅多普勒(TCD)在 TEVAR 不同阶段检测到的微栓子信号(MES)数量,并将其与着陆区、锁骨下动脉血运重建以及术后发病率和死亡率相关联。
在 17 例(85%)胸主动脉瘤(TAA)患者中,20 例患者在 TEVAR 期间使用 TCD 进行监测,其中 3 例(15%)为慢性 B 型主动脉夹层,1 例(5%)为 Crawford Ⅰ型胸腹主动脉瘤(TAAA)。将影像学和医学参数输入联合数据库。TCD 信号被数字化记录整个病例。MES、速度和搏动指数值被输入联合数据库。
在 TEVAR 放置前的诊断阶段和所有病例治疗阶段总共计算的 MES 总数分别为 1081 和 1141。在诊断阶段,猪尾导管放置时产生的 MES 计数最高,在治疗阶段,器械放置时产生的 MES 计数最高。栓塞计数到右侧/左侧是相等的。在诊断阶段,平均每侧出现 9 个 MES,而在治疗阶段,右侧和左侧分别出现 45 和 43 个 MES。MES 总数与术后卒中、短暂性脑缺血发作(P =.0055)和死亡(P =.0053)之间存在显著关联。
TCD 可在 TEVAR 期间检测到微栓子,并能够识别与脑微栓子最相关的手术方面。