Zhu J L, Leadley R J, Geer P G, Wang B C, Goetz K L
Division of Experimental Medicine, St. Luke's Hospital and Foundation, Kansas City, Missouri 64111.
Life Sci. 1990;46(2):139-45. doi: 10.1016/0024-3205(90)90046-t.
This study was designed to determine whether the increase in atriopeptin secretion induced by an intravenous infusion of norepinephrine is mediated directly by adrenergic receptor stimulation or indirectly by the associated increase in atrial pressure. Norepinephrine was infused at 0.5 microgram.kg-1.min-1 for 30 min into both sham-operated (intact) and cardiac-denervated conscious dogs. The infusion increased mean arterial pressure in all dogs. On the other hand, left atrial pressure increased from 5.0 +/- 0.7 to 9.6 +/- 1.6 mmHg (p less than 0.01) in intact dogs, but decreased from 5.5 +/- 1.0 to 2.0 +/- 0.7 (p less than 0.01) in cardiac-denervated dogs. Right atrial pressure changes followed similar trends, but were not significant in the intact group. Plasma atriopeptin increased from 73 +/- 12 to 110 +/- 18 pg/ml (p less than 0.01) as left atrial pressure increased in intact dogs and decreased from 79 +/- 15 to 54 +/- 10 pg/ml (p less than 0.01) as left atrial pressure decreased in cardiac-denervated dogs. The changes in plasma atriopeptin correlated closely with the changes in left atrial pressure (r = 0.941, p less than 0.001) and to a lesser extent with the changes in right atrial pressure (r = 0.413, p less than 0.05). These results suggest that the change in plasma atriopeptin induced by infusion of norepinephrine into conscious dogs is mediated by the concomitant change in atrial pressures.
本研究旨在确定静脉输注去甲肾上腺素所诱导的心房肽分泌增加是直接由肾上腺素能受体刺激介导，还是由相关的心房压力升高间接介导。将去甲肾上腺素以0.5微克·千克⁻¹·分钟⁻¹的剂量输注到假手术（完整）和心脏去神经的清醒犬体内30分钟。输注使所有犬的平均动脉压升高。另一方面，完整犬的左心房压力从5.0±0.7 mmHg升高至9.6±1.6 mmHg（p<0.01），而心脏去神经犬的左心房压力从5.5±1.0 mmHg降至2.0±0.7 mmHg（p<0.01）。右心房压力变化遵循类似趋势，但在完整组中不显著。在完整犬中，随着左心房压力升高，血浆心房肽从73±12 pg/ml增加至110±18 pg/ml（p<0.01）；在心脏去神经犬中，随着左心房压力降低，血浆心房肽从79±15 pg/ml降至54±10 pg/ml（p<0.01）。血浆心房肽的变化与左心房压力的变化密切相关（r = 0.941，p<0.001），与右心房压力的变化相关性较小（r = 0.413，p<0.05）。这些结果表明，向清醒犬输注去甲肾上腺素所诱导的血浆心房肽变化是由心房压力的伴随变化介导的。
