Department of Pharmacology, State-Province Key Laboratory of Biomedicine and Pharmaceutics, Harbin Medical University, China.
Acta Pharmacol Sin. 2011 Mar;32(3):321-8. doi: 10.1038/aps.2010.221.
To investigate whether fluvastatin is able to ameliorate the impaired cardiac function or baroreflex sensitivity (BRS) in rats with type 1 diabetes.
Type 1 diabetic rats were induced by intraperitoneal injection of streptozotocin (STZ) and then administered fluvastatin (1.5, 3.0, and 6.0 mg·kg(-1)·d(-1)) for 30 d. Food and drink intake was recorded every day. Fasting blood glucose (FBG) level, blood lipid level, cardiac function and BRS were measured in diabetic rats after fluvastatin treatment for 30 d.
The polydipsia, polyphagia and abnormal biochemical indexes of blood were significantly ameliorated by the the 3.0- and 6.0-mg doses of fluvastatin in STZ-induced diabetic rats. FBG was decreased in diabetic rats after fluvastatin treatment for 30 d. The left ventricular systolic pressure (LVSP) and the maximum rate of change of left ventricular pressure in the isovolumic contraction and relaxation period (±dp/dt(max)) were elevated, and left ventricular diastolic pressure (LVEDP) was decreased by fluvastatin. The attenuated heart rate responses to arterial blood pressure (ABP) increase induced by phenylephrine (PE) and ABP decrease induced by sodium nitroprusside (SNP) were reversed by the 3.0-mg dose of fluvastatin.
Fluvastatin regulates blood lipid levels and decreases the FBG level in diabetic rats. These responses can protect the diabetic heart from complications by improving cardiac function and BRS.
研究氟伐他汀是否能够改善 1 型糖尿病大鼠的心脏功能障碍或压力感受性反射敏感性（BRS）。
通过腹腔注射链脲佐菌素（STZ）诱导 1 型糖尿病大鼠，并给予氟伐他汀（1.5、3.0 和 6.0 mg·kg(-1)·d(-1)）治疗 30 天。每天记录饮食摄入量。在氟伐他汀治疗 30 天后测量糖尿病大鼠的空腹血糖（FBG）水平、血脂水平、心脏功能和 BRS。
3.0 和 6.0 mg 剂量的氟伐他汀可明显改善 STZ 诱导的糖尿病大鼠的多饮、多食和异常生化指标。氟伐他汀治疗 30 天后，糖尿病大鼠的 FBG 降低。左心室收缩压（LVSP）和等容收缩和舒张期左心室压力最大变化率（±dp/dt(max)）升高，左心室舒张压（LVEDP）降低。氟伐他汀逆转了去氧肾上腺素（PE）引起的动脉血压（ABP）升高和硝普钠（SNP）引起的 ABP 降低引起的心率反应减弱。
氟伐他汀调节血脂水平并降低糖尿病大鼠的 FBG 水平。这些反应可以通过改善心脏功能和 BRS 来保护糖尿病心脏免受并发症的影响。
