Geyer Stefan, Weiss Marcel, Reimann Katja, Lohmann Gabriele, Turner Robert
Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, Germany.
Front Hum Neurosci. 2011 Feb 18;5:19. doi: 10.3389/fnhum.2011.00019. eCollection 2011.
The year 2009 marked the 100th anniversary of the publication of the famous brain map of Korbinian Brodmann. Although a "classic" guide to microanatomical parcellation of the cerebral cortex, it is - from today's state-of-the-art neuroimaging perspective - problematic to use Brodmann's map as a structural guide to functional units in the cortex. In this article we discuss some of the reasons, especially the problematic compatibility of the "post-mortem world" of microstructural brain maps with the "in vivo world" of neuroimaging. We conclude with some prospects for the future of in vivo structural brain mapping: a new approach which has the enormous potential to make direct correlations between microstructure and function in living human brains: "in vivo Brodmann mapping" with high-field magnetic resonance imaging.
2009年是著名的科比尼安·布罗德曼脑图谱发表100周年。尽管它是大脑皮层显微解剖分区的“经典”指南，但从当今最先进的神经成像角度来看，将布罗德曼图谱用作皮层功能单元的结构指南存在问题。在本文中，我们讨论了一些原因，特别是微观结构脑图谱的“死后世界”与神经成像的“体内世界”之间存在的兼容性问题。我们最后展望了体内结构脑图谱的未来：一种具有巨大潜力的新方法，能够在活体人类大脑中直接建立微观结构与功能之间的关联：利用高场磁共振成像进行“体内布罗德曼图谱绘制”。
