18-冠-6 负载的 ICl2-对苯胺和酚的碘化作用。
Iodination of anilines and phenols with 18-crown-6 supported ICl2-.
机构信息
Department of Chemistry, University of Connecticut, Storrs, CT 06269-3060, USA.
出版信息
Org Biomol Chem. 2011 Apr 21;9(8):2987-91. doi: 10.1039/c0ob00926a. Epub 2011 Mar 3.
PMID:21373659
Abstract
A highly crystalline iodinating reagent, {[K·18-C-6]ICl(2)}(n), was synthesized in high yield (93%). The trihalide is supported by an 18-crown-6 macrocycle and forms a coordination polymer in the solid state. This reagent iodinates anilines and phenols efficiently under mild conditions. Controlled mono-iodination with anilines was easily achieved while poly-iodination was observed with phenols.
摘要
一种高结晶的碘化试剂，{[K·18-C-6]ICl(2)}(n)，以高产率（93%）合成。三卤化物由 18-冠-6 大环支撑，并在固态下形成配位聚合物。该试剂在温和条件下有效地碘化苯胺和酚类。用苯胺很容易实现受控的单碘化，而用酚类则观察到多碘化。
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