Sramek John J, Cutler Neal R
Worldwide Clinical Trials, Inc., 401 N. Maple Drive, Beverly Hills, CA 90210, USA.
Curr Top Behav Neurosci. 2011;8:231-49. doi: 10.1007/7854_2010_118.
There is a large body of literature debating whether and how gender affects the metabolism, side-effect profile, and efficacy of antidepressants. Gender differences in antidepressant pharmacokinetics and efficacy profiles have been attributed to not only anatomic and physiological differences between the sexes, but also behavioral factors, comorbid disorders, and gender-specific conditions, such as pregnancy and menopause. Despite the large body of research on this topic, few definitive conclusions regarding effects of gender on antidepressant treatment exist, and much of this research is incomplete, contradictory, or not fully used to optimize the administration of antidepressants and the response to treatment. This chapter will review the latest research on gender-specific effects of antidepressant treatment, focusing on the overall, gender-related differences in efficacy, metabolism, and side-effect profile of antidepressants, and how these differences can be used to better optimize treatment of depression in a clinical setting.
有大量文献在探讨性别是否以及如何影响抗抑郁药的代谢、副作用情况和疗效。抗抑郁药药代动力学和疗效方面的性别差异不仅归因于男女之间的解剖学和生理学差异，还归因于行为因素、共病以及特定性别的状况，如怀孕和更年期。尽管针对这一主题进行了大量研究，但关于性别对抗抑郁治疗影响的明确结论却很少，而且许多此类研究并不完整、相互矛盾，或者未被充分用于优化抗抑郁药的给药和治疗反应。本章将综述抗抑郁治疗性别特异性影响的最新研究，重点关注抗抑郁药在疗效、代谢和副作用方面总体的、与性别相关的差异，以及如何利用这些差异在临床环境中更好地优化抑郁症的治疗。
