Wesseling G J, Vonk J M, Greve L H, Wouters E F
Department of Pulmonary Diseases, State University Limburg, Maastricht, The Netherlands.
Int J Clin Pharmacol Ther Toxicol. 1990 Jan;28(1):33-8.
The influence of cholinergic receptor blockade on the impedance of the respiratory system was studied in 10 healthy volunteers in a frequency spectrum between 4 and 52 Hz by means of the forced pseudo random-noise oscillation technique. Ipratropium bromide was used in the inhaled form in two doses (0.040 and 0.200 mg). Both does caused a significant decrease in oscillatory airway resistance, Rrs. No dose effect on Rrs was found. Both doses caused an increase in the reactance of the respiratory system, Xrs. This increase in Xrs was significantly greater after the inhalation of the higher dose. The effect of both doses on the real part of impedance can be explained by a dilation of the central airways. Furthermore, inhaled ipratropium bromide, especially in the higher dose, led to an increase in the imaginary part of impedance suggesting a decrease in the capacitance of pulmonary structures in normal subjects.
采用强迫伪随机噪声振荡技术，在10名健康志愿者中研究了胆碱能受体阻滞剂对呼吸系统阻抗在4至52赫兹频谱范围内的影响。异丙托溴铵以吸入形式使用两种剂量（0.040和0.200毫克）。两种剂量均导致振荡气道阻力（Rrs）显著降低。未发现Rrs的剂量效应。两种剂量均导致呼吸系统电抗（Xrs）增加。吸入较高剂量后，Xrs的这种增加更为显著。两种剂量对阻抗实部的影响可通过中央气道扩张来解释。此外，吸入异丙托溴铵，尤其是较高剂量时，会导致阻抗虚部增加，提示正常受试者肺结构电容降低。
