Steinhilber Dirk, Haag Rainer, Sisson Adam L
Institute for Chemistry and Biochemistry, Free University Berlin, Berlin, Germany.
Int J Artif Organs. 2011 Feb;34(2):118-22. doi: 10.5301/ijao.2011.6399.
In this paper we describe the preparation of disulfide crosslinked polyglycerol hydrogels by the ring-opening crosslinking polymerization of glycerol and polyethylene glycol-based polyepoxides and Na2S2. Multivalent polyglycerol hydrogels were prepared by acid-catalyzed hydrolysis of remaining epoxide functionalities. Additionally, a near infrared fluorescent dye was encapsulated in the hydrogel network. Our hydrogels show complete degradation in reducing environments and a controlled release of the fluorescence dye was observed. These hydrogels are interesting scaffolds for bioactive substances, which can be released, triggered by the hydrogel degradation.
在本文中，我们描述了通过甘油与聚乙二醇基聚环氧化物和Na2S2的开环交联聚合制备二硫键交联聚甘油水凝胶的方法。通过对剩余环氧化物官能团进行酸催化水解制备了多价聚甘油水凝胶。此外，将一种近红外荧光染料包封在水凝胶网络中。我们的水凝胶在还原环境中显示出完全降解，并观察到荧光染料的可控释放。这些水凝胶是用于生物活性物质的有趣支架，生物活性物质可由水凝胶降解触发释放。
