惊恐障碍中的高碳酸血症与低碳酸血症

Hypercarbia versus hypocarbia in panic disorder.

作者信息

Zandbergen J, Lousberg H H, Pols H, de Loof C, Griez E J

机构信息

State University of Limburg, Department of Clinical Psychiatry, Maastricht, The Netherlands.

出版信息

J Affect Disord. 1990 Feb;18(2):75-81. doi: 10.1016/0165-0327(90)90062-d.

DOI:10.1016/0165-0327(90)90062-d

PMID:2137472

Abstract

In order to compare the panicogenic effects of hypercarbia and hypocarbia in panic disorder (PD), 12 PD patients and 11 healthy controls underwent a 35% CO2 challenge as well as a hyperventilation provocation test in a random cross-over design. Both anxiety and anxiety symptoms proved to be significantly higher during the 35% CO2 challenge in PD patients as compared to the response during 35% CO2 in normals and during hyperventilation in both patients and normals. The results suggest that PD patients are specifically hypersensitive to an increase in pCO2.

摘要

为了比较高碳酸血症和低碳酸血症在惊恐障碍（PD）中的致惊恐作用，12名惊恐障碍患者和11名健康对照者采用随机交叉设计，接受了35%二氧化碳激发试验以及过度通气激发试验。与正常人群在35%二氧化碳激发试验时的反应以及患者和正常人群在过度通气时的反应相比，惊恐障碍患者在35%二氧化碳激发试验期间的焦虑及焦虑症状明显更严重。结果表明，惊恐障碍患者对动脉血二氧化碳分压升高具有特异性高敏感性。