Dugan L O, Dugan D A, Dugan W M
Methodist Hospital, Indianapolis, IN.
Indiana Med. 1990 Feb;83(2):114-6.
In the evaluation of patients older than 50 with severe back pain and chronic simple anemia, the diagnosis of multiple myeloma must be considered. Due to the age group affected, degenerative changes on spinal films may be misdiagnosed as osteoporosis, and anemia may be attributed to iron deficiency. These errors can be avoided in more than 99% of the cases of multiple myeloma by ordering a serum protein electrophoresis (SPE). Abnormal SPE patterns include monoclonal gammopathy and hypogammaglobulinemia. In the detection of multiple myeloma, magnetic resonance imaging has been found superior to plain radiograph, computed tomography and bone scan.
在评估年龄超过50岁且患有严重背痛和慢性单纯性贫血的患者时，必须考虑多发性骨髓瘤的诊断。由于受影响的年龄组，脊柱X光片上的退行性改变可能被误诊为骨质疏松症，而贫血可能归因于缺铁。通过进行血清蛋白电泳（SPE），在超过99%的多发性骨髓瘤病例中可以避免这些错误。异常的SPE模式包括单克隆丙种球蛋白病和低丙种球蛋白血症。在多发性骨髓瘤的检测中，已发现磁共振成像优于普通X光片、计算机断层扫描和骨扫描。
