Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.
Acta Oncol. 2011 Oct;50(7):1098-104. doi: 10.3109/0284186X.2011.562240. Epub 2011 Mar 4.
The high interstitial fluid pressure (IFP) in solid tumors restricts the access to nutrients, oxygen and drugs.
We investigated the ability of the peptide AF-16, involved in water and ion transfer through cell membranes, to lower the IFP in two different solid rat mammary tumors, one chemically induced, slowly growing, and the other transplantable, and rapidly progressing having high cellularity. AF-16 was administered either in the tumor capsule, intranasally or intravenously. The IFP was measured by a miniature fiber optic device.
AF-16 significantly lowered the IFP in both the slowly and the rapidly progressing tumors, whether administrated locally or systemically. The AF-16 induced IFP reduction was maximal after 90 min, lasted at least 3 h, and returned to pretreatment levels in less than 24 h. Topical AF-16 transiently reduced the IFP in the DMBA tumors from 17.7 ± 4.2 mmHg to 8.6 ± 2.1 mmHg.
We conclude that AF-16 transiently and reversibly lowered the high IFP in solid tumors during a few hours, which might translate into improved therapeutic efficacy.
固体肿瘤中的高间质液压力（IFP）限制了营养物质、氧气和药物的进入。
我们研究了参与水和离子通过细胞膜转移的肽 AF-16 降低两种不同的固体大鼠乳腺肿瘤 IFP 的能力，一种是化学诱导的、生长缓慢的肿瘤，另一种是可移植的、细胞密度高的快速进展的肿瘤。AF-16 通过微型光纤设备进行测量。
AF-16 无论是局部还是系统给药，均能显著降低缓慢和快速进展的肿瘤的 IFP。AF-16 诱导的 IFP 降低在 90 分钟后达到最大值，至少持续 3 小时，不到 24 小时即可恢复到预处理水平。局部给予 AF-16 可使 DMBA 肿瘤的 IFP 从 17.7 ± 4.2 mmHg 短暂降低至 8.6 ± 2.1 mmHg。
我们得出结论，AF-16 可在数小时内短暂和可逆地降低固体肿瘤中的高 IFP，这可能转化为改善治疗效果。
