Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Nîmes, Faculté de Médecine de Montpellier-Nîmes, Université Montpellier I, Montpellier, France.
Clin Microbiol Infect. 2011 Jul;17(7):1068-70. doi: 10.1111/j.1469-0691.2011.03471.x. Epub 2011 Mar 7.
We describe here the first case of osteitis caused by Candida haemulonii in a young immunocompetent patient. This patient presented a history of severe peripheral vascular disease associated with a lack of hygienic conditions as the only risk factors for such an uncommon infection. Clinical signs and histological examination allowed us to determine that it was a C. haemulonii infection and not colonization. The outcome was favourable with oral voriconazole therapy and surgical revascularization. An environmental cause of such infections is most probable, as C. haemulonii has previously been isolated from different non-human sources. Identification methods, results obtained with three in vitro antifungal susceptibility methods and clinical features are reported.
我们在此描述了首例由海氏假丝酵母引起的骨髓炎,发生于一位年轻的免疫功能正常的患者。该患者有严重外周血管疾病病史,同时伴有卫生条件较差,这是导致这种不常见感染的唯一危险因素。临床症状和组织学检查结果表明这是海氏假丝酵母感染而不是定植。口服伏立康唑治疗和手术血运重建后,患者转归良好。由于海氏假丝酵母以前曾从不同的非人类来源中分离出来,因此这种感染最有可能是由环境因素引起的。本文报告了鉴定方法、三种体外抗真菌药敏试验的结果和临床特征。