替利罗苷衍生物通过 AMPK 增强肌肉细胞中的 GLUT4 易位。
Tiliroside-derivatives enhance GLUT4 translocation via AMPK in muscle cells.
机构信息
Department of Immunology, Key Laboratory of Immuno Microenvironment and Disease of the Educational Ministry of China, Tianjin Medical University, Tianjin 300070, China.
出版信息
Diabetes Res Clin Pract. 2011 May;92(2):e41-6. doi: 10.1016/j.diabres.2011.02.009. Epub 2011 Mar 3.
Tiliroside isolated from Chinese herb Potentilla chinensis showed therapeutic activities in diabetes. We synthesized 7 tiliroside-derivatives and examined their effects on surface GLUT4myc levels in muscle cells. Derivatives 2a and 3 increased surface GLUT4myc levels, and derivative 3 has the greatest potential. AMPK may be involved in tiliroside-derivatives-regulated GLUT4myc traffic.
从中国草药委陵菜中分离得到的三叶豆紫檀苷在糖尿病治疗中具有活性。我们合成了 7 种三叶豆紫檀苷衍生物，并检测了它们对肌细胞表面 GLUT4myc 水平的影响。衍生物 2a 和 3 增加了表面 GLUT4myc 水平，其中衍生物 3 具有最大的潜力。AMPK 可能参与了三叶豆紫檀苷衍生物调节 GLUT4myc 转运的过程。
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