Department of Medical Toxicology, Banner Good Samaritan Medical Center, Phoenix, AZ 85006, USA.
Ann Emerg Med. 2011 Jul;58(1):80-2. doi: 10.1016/j.annemergmed.2010.10.015. Epub 2011 Mar 4.
Paliperidone, or 9-hydroxy risperidone, is the newest atypical antipsychotic agent to be approved for use by the Food and Drug Administration. Despite being the primary active metabolite of risperidone, paliperidone differs in several ways from risperidone. The most notable difference is that paliperidone is formulated as an extended-release product. We present a case of a 14-year-old, 59-kg girl with a history of psychosis and major depressive disorder who developed toxicity after an ingestion of 180 mg (3.1 mg/kg) of paliperidone. This case is not only one of the first cases of paliperidone overdose described in the literature but also is unique in that it describes delayed onset of toxicity, as well as extended duration of symptoms.
帕利哌酮，或 9-羟基利培酮，是最近被美国食品和药物管理局批准使用的新型非典型抗精神病药物。尽管是利培酮的主要活性代谢物，但帕利哌酮在几个方面与利培酮不同。最显著的区别是帕利哌酮被制成了一种缓释产品。我们报告了一例 14 岁、59 公斤的女孩，有精神病和重度抑郁症病史，摄入 180 毫克（3.1 毫克/公斤）帕利哌酮后出现中毒。该病例不仅是文献中首次描述的帕利哌酮过量的病例之一，而且还具有独特之处，即描述了毒性的延迟发作以及症状的持续时间延长。
