Cardiovascular Risk and Nutrition, Cardiovascular Epidemiology and Genetics, and Human Pharmacology and Clinical Neurosciences Research Groups, Research Institute Hospital del Mar (IMIM), Barcelona 08003, Spain.
Clin Nutr. 2011 Aug;30(4):490-3. doi: 10.1016/j.clnu.2011.01.013. Epub 2011 Mar 3.
BACKGROUND & AIM: Oxidized LDL (oxLDL) is a highly immunogenic particle that plays a key role in the development of atherosclerosis. Some data suggest a protective role of OxLDL autoantibodies (OLAB) in atherosclerosis. Our aim was to assess the effect of olive oil polyphenols on the immunogenicity of oxLDL to autoantibody generation.
In a crossover, controlled trial, 200 healthy men were randomly assigned to 3-week sequences of 25 mL/day of 3 olive oils with high (366 mg/kg), medium (164 mg/kg), and low (2.7 mg/kg) phenolic content.
Plasma OLAB concentration was inversely associated with oxLDL (p < 0.001). Olive oil phenolic content increased OLAB generation, with the effect being stronger at higher concentrations of oxLDL (p = 0.020 for interaction). A direct relationship was observed between OLAB and the total olive oil phenol content in LDL (r = 0.209; p = 0.014). OLAB concentrations, adjusted for oxLDL, increased directly in a dose-dependent manner with the polyphenol content of the olive oil administered (p = 0.023).
Olive oil polyphenols promote OLAB generation. This effect is stronger at higher concentrations of lipid oxidative damage.
氧化型低密度脂蛋白（oxLDL）是一种具有高度免疫原性的颗粒，在动脉粥样硬化的发生发展中起关键作用。一些数据表明，oxLDL 自身抗体（OLAB）在动脉粥样硬化中具有保护作用。我们的目的是评估橄榄油多酚对 oxLDL 免疫原性产生 OLAB 的影响。
在一项交叉对照试验中，200 名健康男性被随机分为 3 组，分别接受 3 种橄榄油（高、中、低酚含量组），每组 25mL/天，共 3 周。
血浆 OLAB 浓度与 oxLDL 呈负相关（p<0.001）。橄榄油酚含量增加 OLAB 的产生，在 oxLDL 浓度较高时效果更强（p=0.020 交互作用）。OLAB 与 LDL 中橄榄油总酚含量呈直接关系（r=0.209；p=0.014）。调整 oxLDL 后，OLAB 浓度与橄榄油中多酚含量呈直接剂量依赖性增加（p=0.023）。
橄榄油多酚促进 OLAB 的产生。这种作用在脂质氧化损伤浓度较高时更强。
