橄榄油多酚对氧化型低密度脂蛋白抗体的影响。一项随机临床试验。

The effect of olive oil polyphenols on antibodies against oxidized LDL. A randomized clinical trial.

机构信息

Cardiovascular Risk and Nutrition, Cardiovascular Epidemiology and Genetics, and Human Pharmacology and Clinical Neurosciences Research Groups, Research Institute Hospital del Mar (IMIM), Barcelona 08003, Spain.

出版信息

Clin Nutr. 2011 Aug;30(4):490-3. doi: 10.1016/j.clnu.2011.01.013. Epub 2011 Mar 3.

DOI:10.1016/j.clnu.2011.01.013

PMID:21376434

Abstract

BACKGROUND & AIM: Oxidized LDL (oxLDL) is a highly immunogenic particle that plays a key role in the development of atherosclerosis. Some data suggest a protective role of OxLDL autoantibodies (OLAB) in atherosclerosis. Our aim was to assess the effect of olive oil polyphenols on the immunogenicity of oxLDL to autoantibody generation.

METHODS

In a crossover, controlled trial, 200 healthy men were randomly assigned to 3-week sequences of 25 mL/day of 3 olive oils with high (366 mg/kg), medium (164 mg/kg), and low (2.7 mg/kg) phenolic content.

RESULTS

Plasma OLAB concentration was inversely associated with oxLDL (p < 0.001). Olive oil phenolic content increased OLAB generation, with the effect being stronger at higher concentrations of oxLDL (p = 0.020 for interaction). A direct relationship was observed between OLAB and the total olive oil phenol content in LDL (r = 0.209; p = 0.014). OLAB concentrations, adjusted for oxLDL, increased directly in a dose-dependent manner with the polyphenol content of the olive oil administered (p = 0.023).

CONCLUSION

Olive oil polyphenols promote OLAB generation. This effect is stronger at higher concentrations of lipid oxidative damage.

摘要

背景与目的

氧化型低密度脂蛋白（oxLDL）是一种具有高度免疫原性的颗粒，在动脉粥样硬化的发生发展中起关键作用。一些数据表明，oxLDL 自身抗体（OLAB）在动脉粥样硬化中具有保护作用。我们的目的是评估橄榄油多酚对 oxLDL 免疫原性产生 OLAB 的影响。

方法

在一项交叉对照试验中，200 名健康男性被随机分为 3 组，分别接受 3 种橄榄油（高、中、低酚含量组），每组 25mL/天，共 3 周。

结果

血浆 OLAB 浓度与 oxLDL 呈负相关（p<0.001）。橄榄油酚含量增加 OLAB 的产生，在 oxLDL 浓度较高时效果更强（p=0.020 交互作用）。OLAB 与 LDL 中橄榄油总酚含量呈直接关系（r=0.209；p=0.014）。调整 oxLDL 后，OLAB 浓度与橄榄油中多酚含量呈直接剂量依赖性增加（p=0.023）。