Fetal Maternal Medicine Unit, St George's, University of London, Cranmer Terrace, London SW17 0RE, UK.
Best Pract Res Clin Obstet Gynaecol. 2011 Jun;25(3):343-54. doi: 10.1016/j.bpobgyn.2011.01.002. Epub 2011 Mar 4.
Pre-eclampsia remains an important cause of maternal and perinatal mortality. The ability to predict the most severe forms of pre-eclampsia would allow closer surveillance and earlier intervention to improve outcomes. Although no definitive preventative treatment has been found to date, it is likely that prospective treatments would need to start early in pregnancy to alter pathogenesis. Following recent advances in the understanding of the pathogenesis of this complex syndrome, new predictive tests are being evaluated. The most promising models incorporate biochemical and biophysical tests that combine assessments of placentation and maternal disease susceptibility.
子痫前期仍然是孕产妇和围产儿死亡的一个重要原因。能够预测最严重的子痫前期形式将有助于进行更密切的监测和更早的干预，以改善结局。尽管迄今为止尚未找到明确的预防治疗方法，但很可能需要在妊娠早期开始前瞻性治疗，以改变发病机制。随着对这种复杂综合征发病机制的理解的最新进展，新的预测性测试正在得到评估。最有前途的模型包括生化和生物物理测试，这些测试结合了对胎盘和母体疾病易感性的评估。
