Centre for Mathematical Biology, University of Bath, Bath BA2 7AY, UK.
Math Biosci. 2011 Jun;231(2):126-34. doi: 10.1016/j.mbs.2011.02.009. Epub 2011 Mar 4.
Vaccination against the human papillomavirus (HPV) is a recent development in the UK. This paper uses an optimal control model to explore how best to target vaccination. We find that the vaccination of sexually active individuals has a greater impact on disease control than the vaccination of sexually non-active individuals. Extending the model to include male vaccination, we find that including males in a vaccination strategy is cost-effective. We compare the optimal control solution to that from a constant control model and show that the optimal control model is more efficient at forcing the system to a disease-controlled steady state.
人乳头瘤病毒（HPV）疫苗接种在英国是一个新的发展。本文使用最优控制模型来探讨如何最好地针对疫苗接种。我们发现，对性行为活跃的个体进行疫苗接种比对性行为不活跃的个体进行疫苗接种对疾病控制的影响更大。将模型扩展到包括男性疫苗接种，我们发现将男性纳入疫苗接种策略是具有成本效益的。我们将最优控制解决方案与常数控制模型进行比较，并表明最优控制模型在将系统强制推向疾病控制的稳态方面更有效率。
