Rolland R, van der Heijden P F
Department of Obstetrics and Gynecology, University Hospital, Nijmegen, The Netherlands.
Am J Obstet Gynecol. 1990 Feb;162(2):586-8. doi: 10.1016/0002-9378(90)90437-c.
A double-blind, double-dummy, 6-month multicenter study comparing the effects of nafarelin and danazol in the treatment of endometriosis was completed recently by investigators from 13 institutions in seven European countries. The 194 patients (aged 18 to 45 years) selected for the study were divided into two groups. One group received nafarelin, 200 micrograms twice daily, and placebo capsules identical to danazol, twice daily. The other group received danazol capsules, 200 mg twice daily, and a placebo nasal spray identical to nafarelin, twice daily. A comparison of decreases in both groups of American Fertility Society endometriosis scores and in severity scores developed by the investigators indicates that nafarelin and danazol are equally effective in the treatment of endometriosis.
最近，来自欧洲七个国家13个机构的研究人员完成了一项双盲、双模拟、为期6个月的多中心研究，比较那法瑞林和达那唑治疗子宫内膜异位症的效果。入选该研究的194名患者（年龄在18至45岁之间）被分为两组。一组患者每日两次接受200微克那法瑞林及与达那唑外观相同的安慰剂胶囊。另一组患者每日两次接受200毫克达那唑胶囊及与那法瑞林外观相同的安慰剂鼻喷雾剂。对两组美国生育协会子宫内膜异位症评分及研究人员制定的严重程度评分的下降情况进行比较表明，那法瑞林和达那唑在治疗子宫内膜异位症方面同样有效。
