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高敏儿科患者心脏移植的结果

Outcomes of cardiac transplantation in highly sensitized pediatric patients.

作者信息

Scott Victoria, Williams Ryan J, Levi Daniel S

机构信息

Division of Pediatric Cardiology, David Geffen School of Medicine at UCLA, B2-427 MDCC, 10833 Le Conte Ave, Los Angeles, CA 90095-1743, USA.

出版信息

Pediatr Cardiol. 2011 Jun;32(5):615-20. doi: 10.1007/s00246-011-9928-5. Epub 2011 Mar 6.

DOI:10.1007/s00246-011-9928-5
PMID:21380717
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3094652/
Abstract

Despite aggressive immunosuppressive therapy, pediatric orthotopic heart transplant (OHT) candidates with elevated pre-transplant panel reactive antibody (PRA) carry an increased risk of rejection and early graft failure following transplantation. This study has aimed to more specifically evaluate the outcomes of transplant candidates stratified by PRA values. Records of pediatric patients listed for OHT between April 2004 and July 2008 were reviewed (n = 101). Survival analysis was performed comparing patients with PRA < 25 to those with PRA > 25, as well as patients with PRA < 80 and PRA > 80. Patients with PRA > 25 had decreased survival compared with those with PRA < 25 after listing (P = 0.004). There was an even greater difference in survival between patients with PRA > 80 and those with PRA < 80 (P = 0.002). Similar analyses for the patients who underwent successful transplantation showed no significant difference in post-transplant survival between patients with a pre-transplant PRA > 25 and those with PRA < 25 (P = 0.23). A difference approaching significance was noted for patients with PRA > 80 compared with PRA < 80 (P = 0.066). Patients with significantly elevated pre-transplant PRAs at the time of listing have a significantly worse outcome compared to those with moderately increased PRA values or non-sensitized patients. Further study is necessary to guide physician and family treatment decisions at the time of listing.

摘要

尽管采用了积极的免疫抑制治疗，但移植前群体反应性抗体（PRA）升高的小儿原位心脏移植（OHT）候选者在移植后发生排斥反应和早期移植物失败的风险增加。本研究旨在更具体地评估按PRA值分层的移植候选者的结局。回顾了2004年4月至2008年7月期间登记等待OHT的小儿患者记录（n = 101）。进行生存分析，比较PRA < 25的患者与PRA > 25的患者，以及PRA < 80和PRA > 80的患者。登记后，PRA > 25的患者与PRA < 25的患者相比，生存率降低（P = 0.004）。PRA > 80的患者与PRA < 80的患者之间的生存率差异更大（P = 0.002）。对成功进行移植的患者进行的类似分析显示，移植前PRA > 25的患者与PRA < 25的患者在移植后的生存率无显著差异（P = 0.23）。与PRA < 80的患者相比，PRA > 80的患者差异接近显著（P = 0.066）。与PRA值中度升高的患者或未致敏患者相比，登记时移植前PRA显著升高的患者结局明显更差。有必要进行进一步研究，以指导医生和家属在登记时做出治疗决策。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e19d/3094652/7f676e8166b4/246_2011_9928_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e19d/3094652/135345ef6462/246_2011_9928_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e19d/3094652/b7ff72dbf696/246_2011_9928_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e19d/3094652/876db9efa681/246_2011_9928_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e19d/3094652/7f676e8166b4/246_2011_9928_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e19d/3094652/135345ef6462/246_2011_9928_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e19d/3094652/b7ff72dbf696/246_2011_9928_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e19d/3094652/876db9efa681/246_2011_9928_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e19d/3094652/7f676e8166b4/246_2011_9928_Fig4_HTML.jpg

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本文引用的文献

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J Heart Lung Transplant. 2007 Nov;26(11):1163-9. doi: 10.1016/j.healun.2007.07.042. Epub 2007 Sep 27.
2
Pediatric heart transplantation in human leukocyte antigen sensitized patients: evolving management and assessment of intermediate-term outcomes in a high-risk population.人类白细胞抗原致敏患者的小儿心脏移植：高危人群中期结局的管理进展与评估
Circulation. 2007 Sep 11;116(11 Suppl):I172-8. doi: 10.1161/CIRCULATIONAHA.107.709022.
3
J Clin Apher. 2018 Aug;33(4):469-479. doi: 10.1002/jca.21622. Epub 2018 Mar 10.
4
Study rationale, design, and pretransplantation alloantibody status: A first report of Clinical Trials in Organ Transplantation in Children-04 (CTOTC-04) in pediatric heart transplantation.研究背景、设计和移植前同种异体抗体状态：儿童器官移植临床试验-04（CTOTC-04）在儿科心脏移植中的首次报告。
Am J Transplant. 2018 Sep;18(9):2135-2147. doi: 10.1111/ajt.14695. Epub 2018 Mar 23.
5
Significance of Anti-HLA Antibodies on Adult and Pediatric Heart Allograft Outcomes.抗HLA抗体对成人及儿童心脏移植预后的意义。
Front Immunol. 2017 Jan 27;8:4. doi: 10.3389/fimmu.2017.00004. eCollection 2017.
6
Human leukocyte antigens and alloimmunization in heart transplantation: an open debate.心脏移植中的人类白细胞抗原与同种免疫：一场公开辩论
J Cardiovasc Transl Res. 2014 Oct;7(7):664-75. doi: 10.1007/s12265-014-9587-z. Epub 2014 Sep 5.
7
Challenges with sensitized recipients in pediatric heart transplantation.小儿心脏移植中致敏受者面临的挑战。
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