Oostdijk W, Hümmelink R, Odink R J, Partsch C J, Drop S L, Lorenzen F, Sippell W G, van der Velde E A, Schultheiss H
Department of Paediatrics, University of Leiden, The Netherlands.
Eur J Pediatr. 1990 Feb;149(5):308-13. doi: 10.1007/BF02171554.
A total of 82 patients (74 girls, 8 boys) are presently participating in an international multicentre trial for treatment of central precocious puberty (CPP) with a slow release gonadotropin-releasing hormone (GnRH) agonist depot preparation: Decapeptyl-Depot (DD). Of these patients, 53 (3 boys) were previously untreated (group 1) and 29 (5 boys) have been treated before with either a short-acting GnRH analogue or cyproterone acetate (group 2). Fifty-one patients (44 girls, 7 boys) were treated with DD for 12 months or more. Basal plasma luteinizing hormone (LH) levels decreased in both groups after 1 year of therapy. The LH response to intravenous GnRH was reduced in both groups. Basal plasma follicle stimulating hormone (FSH) levels decreased in both groups. Stimulated FSH levels were reduced in both groups after 1 year of DD treatment. Plasma oestradiol levels in the girls decreased to prepubertal levels in both groups. In all patients the clinical signs of precocious gonadarche such as breast development and menstruations (girls) and an increased testis volume (boys), did not further progress and sometimes regressed in several patients. Growth velocity decreased in the girls of group 1 from 9.0 +/- 0.72 cm/year (mean +/- SEM) in the last half-year before treatment to 6.3 +/- 0.50 in the first half-year of treatment (P less than 0.01) and to 4.5 +/- 0.23 cm/year in the second half-year (P less than 0.01). After 12 months a stabilization of growth velocity was observed.(ABSTRACT TRUNCATED AT 250 WORDS)
共有82例患者（74名女孩，8名男孩）目前正在参与一项国际多中心试验，该试验旨在使用缓释促性腺激素释放激素（GnRH）激动剂长效注射剂：曲普瑞林长效注射剂（DD）治疗中枢性性早熟（CPP）。在这些患者中，53例（3名男孩）此前未接受过治疗（第1组），29例（5名男孩）之前曾接受过短效GnRH类似物或醋酸环丙孕酮治疗（第2组）。51例患者（44名女孩，7名男孩）接受DD治疗12个月或更长时间。治疗1年后，两组的基础血浆促黄体生成素（LH）水平均下降。两组对静脉注射GnRH的LH反应均降低。两组的基础血浆促卵泡生成素（FSH）水平均下降。DD治疗1年后，两组的刺激FSH水平均降低。两组女孩的血浆雌二醇水平均降至青春期前水平。在所有患者中，性早熟的临床体征，如乳房发育和月经（女孩）以及睾丸体积增大（男孩），均未进一步进展，在一些患者中有时还会消退。第1组女孩的生长速度从治疗前最后半年的9.0±0.72厘米/年（平均值±标准误）降至治疗上半年的6.3±0.50厘米/年（P<0.01），并在下半年降至4.5±0.23厘米/年（P<0.01）。12个月后观察到生长速度稳定。（摘要截断于250字）
