Sobolev S G, Frolova T V, Pogodina V V
Vopr Virusol. 2010 Nov-Dec;55(6):31-5.
The brain cells of adult albino rats underwent electron microscopic study after intracerebral infection with tickborne encephalitis virus (TBEV) strains isolated after long persistence in monkeys, Syrian hamsters, and a patient with chronic tick-borne encephalitis. The TBEV morphogenesis scheme was shown to be fundamentally similar for both high-virulent and long persistent TBEV strains. Data on the budding of newly forming particles on the degranulated membranes of the irregular endoplasmic network are presented. The morphogenesis and molecular mechanisms of TBEV reproduction call for further comprehensive studies.
用在猴子、叙利亚仓鼠和一名慢性蜱传脑炎患者体内长期存活后分离出的蜱传脑炎病毒（TBEV）株对成年白化大鼠进行脑内感染后，对其脑细胞进行了电子显微镜研究。结果表明，高毒力和长期存活的TBEV株的TBEV形态发生模式基本相似。本文提供了关于新形成的颗粒在不规则内质网脱颗粒膜上出芽的相关数据。TBEV繁殖的形态发生和分子机制需要进一步全面研究。
