[石棉水泥行业及其产品致癌风险的实验原理]

[Experimental rationale for carcinogenic risk of asbestos cement industry and its products].

作者信息

Pylev D N, Smirnova O V, Vasil'eva L A, Khrustalev S A, Vezentsev A I, Gudkova E A, Naumova L N

出版信息

Gig Sanit. 2010 Nov-Dec(6):61-5.

Abstract

During intraperitoneal administration of dispersiveness-comparable chrysotile or asbestos cement fibers to rats (20 mg thrice), mesotheliomas were found in 45.1 and 7.7% of cases respectively. Asbestos cement dust induced tumors in 2.5% of cases, which is of biological importance. Cement or freeze asbestos destruction cement dust failed to cause tumors. The latter were not detected in a control group receiving physiological saline. Asbestos cement fibers and fascicles are covered by a cement matrix. Fiber amorphization gradually occurs. In lung tissue, there may be destruction of the cement coat of fascicles and release of native chrysotile fibers that are carcinogenic.

摘要

在向大鼠腹腔内注射分散性相当的温石棉或石棉水泥纤维（每次20毫克，共三次）后，间皮瘤的发生率分别为45.1%和7.7%。石棉水泥粉尘在2.5%的病例中诱发肿瘤，这具有生物学重要性。水泥或冷冻石棉破坏水泥粉尘未能诱发肿瘤。在接受生理盐水的对照组中未检测到肿瘤。石棉水泥纤维和纤维束被水泥基质覆盖。纤维逐渐发生无定形化。在肺组织中，纤维束的水泥涂层可能会遭到破坏，从而释放出具有致癌性的天然温石棉纤维。